单剂量环丙沙星与3天诺氟沙星治疗女性单纯性尿路感染的比较。
Single-dose ciprofloxacin versus 3 days of norfloxacin in uncomplicated urinary tract infections in women.
作者信息
Auquer F, Cordón F, Gorina E, Caballero J C, Adalid C, Batlle J
机构信息
Subdivisió d'Atenció Primària, Institut Català de la Salut, Unitat Docent de Medicina de Família i Comunitària, c/Santa Clara, 33-35 Girona 17001, Spain.
出版信息
Clin Microbiol Infect. 2002 Jan;8(1):50-4.
A double-blind, randomized controlled study to evaluate the efficacy and safety of a single dose of 500 mg of ciprofloxacin versus 3 days 400 mg twice-daily of norfloxacin in uncomplicated urinary tract infection in women was designed. Patients underwent four visits: baseline, and at 3, 7 and 28 days. The main efficacy variables were clinical and microbiological outcome at day 7. Analyses on both valid patients and intention-to-treat populations were performed. Two hundred and twenty-six patients (114 receiving ciprofloxacin and 112 receiving norfloxacin) were considered valid for efficacy evaluation. Bacteriologic cure was 91.2% in the ciprofloxacin group and 91.9% in the norfloxacin group. Clinical resolution was 91.2 and 93.8%, respectively. Both treatments were equally efficacious (P = 0.016).
设计了一项双盲、随机对照研究，以评估单剂量500毫克环丙沙星与每日两次服用400毫克诺氟沙星、连用3天治疗女性单纯性尿路感染的疗效和安全性。患者需进行四次访视：基线访视以及在第3、7和28天的访视。主要疗效变量为第7天的临床和微生物学结果。对有效患者和意向性治疗人群均进行了分析。226例患者（114例接受环丙沙星治疗，112例接受诺氟沙星治疗）被认为可进行疗效评估。环丙沙星组的细菌学治愈率为91.2%，诺氟沙星组为91.9%。临床缓解率分别为91.2%和93.8%。两种治疗同样有效（P = 0.016）。
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