哌替啶和异丙嗪对产程活跃期胎儿心率指标的影响。

The effect of meperidine and promethazine on fetal heart rate indices during the active phase of labor.

作者信息

Solt Ido, Ganadry Sohair, Weiner Zeev

机构信息

Department of Obstetrics and Gynecology, Rambam Medical Center, Haifa, Israel.

出版信息

Isr Med Assoc J. 2002 Mar;4(3):178-80.

PMID:11908257

Abstract

BACKGROUND

Visual interpretation of fetal heart rare monitoring is subject to intra- and inter-observer variability.

OBJECTIVE

To examine the effect of intrapartum administration of meperidine and promethazine on fetal heart activity measured objectively by a computerized system.

METHODS

Fourteen healthy women with normal pregnancies at term were studied during the active phase of labor. Fetal heart rate was recorded with the Oxford Sonicaid system 8000. Recordings were performed for 40 minutes prior to and after maternal intravenous administration of meperidine 50 mg with promethazine 25 mg.

RESULTS

The combination of meperidine and promethazine caused a significant decrease in the number of accelerations of 10 beats per minute (9.7 versus 2.6, P = 0.002) and 15 beats per minute (5.2 vs. 1.4, P = 0.003), time spent in episodes of high variation (14.8 vs. 2.0, P = 0.005) and short-term variation (7.8 vs. 5.0, P = 0.003). On the other hand there was an increase in the time spent in episodes of low variation (5.3 vs. 19.7, P = 0.009).

CONCLUSIONS

Maternal administration of meperidine with promethazine has a significant effect on FHR indices during the active phase of normal labor.

摘要

背景

胎儿心率监测的视觉解读存在观察者内和观察者间的差异。

目的

研究分娩期静脉注射哌替啶和异丙嗪对通过计算机系统客观测量的胎儿心脏活动的影响。

方法

对14名足月正常妊娠的健康女性在分娩活跃期进行研究。使用牛津Sonicaid系统8000记录胎儿心率。在孕妇静脉注射50毫克哌替啶和25毫克异丙嗪之前和之后各记录40分钟。

结果

哌替啶和异丙嗪联合使用导致每分钟10次心跳加速的次数显著减少（9.7对2.6，P = 0.002）以及每分钟15次心跳加速的次数显著减少（5.2对1.4，P = 0.003），高变异期所花时间（14.8对2.0，P = 0.005）和短期变异（7.8对5.0，P = 0.003）减少。另一方面，低变异期所花时间增加（5.3对19.7，P = 0.009）。