阿尔茨海默病精神病性表型的家族风险增加。
Increased familial risk of the psychotic phenotype of Alzheimer disease.
作者信息
Sweet R A, Nimgaonkar V L, Devlin B, Lopez O L, DeKosky S T
机构信息
Division of Geriatrics and Neuropsychiatry, School of Medicine, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
出版信息
Neurology. 2002 Mar 26;58(6):907-11. doi: 10.1212/wnl.58.6.907.
BACKGROUND
Psychotic symptoms in patients with AD (AD with psychosis [AD+P]) define a phenotype characterized by more rapid cognitive and functional decline and a liability to aggressive behaviors.
OBJECTIVE
To determine if AD+P aggregates within families.
METHODS
Case-control study of AD+P frequency in 461 siblings of 371 probands diagnosed with AD. All siblings were ascertained as part of a genetic investigation and also were diagnosed with AD. Statistical analysis used Generalized Estimating Equations to adjust for clustering within families.
RESULTS
AD+P in probands was associated with a significantly increased risk for AD+P in family members (OR, 2.41; 95% CI 1.46-4.0; p = 0.0006). The correlation among siblings for AD+P status was modest: 0.16.
CONCLUSION
AD+P demonstrates familial aggregation. Further studies are required to investigate a possible genetic basis of AD+P.
背景
阿尔茨海默病患者（伴有精神病性症状的阿尔茨海默病[AD+P]）的精神病性症状定义了一种表型，其特征为认知和功能衰退更快，且有攻击行为倾向。
目的
确定AD+P是否在家族中聚集。
方法
对371例诊断为AD的先证者的461名同胞进行AD+P频率的病例对照研究。所有同胞均作为基因研究的一部分被确定，且也被诊断为AD。统计分析使用广义估计方程来调整家族内的聚类情况。
结果
先证者中的AD+P与家庭成员中AD+P风险显著增加相关（比值比[OR]，2.41；95%可信区间[CI] 1.46 - 4.0；p = 0.0006）。同胞间AD+P状态的相关性适中：0.16。
结论
AD+P表现出家族聚集性。需要进一步研究来探究AD+P可能的遗传基础。
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