Zhao Yu, Yu Li, Wang Quanshun, Lou Fangding, Pu Jing
Hematology Department, The General Hospital of PLA. Beijing 100853, China.
Zhonghua Nei Ke Za Zhi. 2002 Mar;41(3):183-5.
To evaluate the relationship between the expression of lung resistance-related protein (lrp) gene or multidrug resistance-associated protein (mrp) gene and prognosis in untreated acute leukemia (AL) patients.
Reverse transcriptase-polymerase chain reaction (RT-PCR) was used to examine the expression of lrp and mrp gene in 58 newly diagnosed AL patients.
The positive rate of lrp and mrp gene expression in newly diagnosed acute lymphocytic leukemia (ALL) group was 15.0% and 40.0% and it was 15.8% and 42.1% in newly diagnosed acute nonlymphocytic leukemia (ANLL) group. In both the ALL and ANLL groups, the difference of the first complete remission rate in lrp negative and in lrp positive patients was not significant (P > 0.05), the same results were found with mrp gene. The difference of the first complete remission rate between lrp(+)/mrp(+) and lrp(-)/mrp(-) patients was significant (P < 0.05). There was no relationship between lrp and mrp gene.
Neither lrp nor mrp gene as a single indicator to forecast original multidrug resistance is sensitive, but lrp combined with mrp as one indicator will be sensitive.
评估肺耐药相关蛋白（LRP）基因或多药耐药相关蛋白（MRP）基因的表达与初治急性白血病（AL）患者预后的关系。
采用逆转录聚合酶链反应（RT-PCR）检测58例新诊断AL患者LRP和MRP基因的表达。
新诊断急性淋巴细胞白血病（ALL）组LRP和MRP基因表达阳性率分别为15.0%和40.0%，新诊断急性非淋巴细胞白血病（ANLL）组分别为15.8%和42.1%。在ALL组和ANLL组中，LRP阴性和阳性患者首次完全缓解率的差异均无统计学意义（P>0.05），MRP基因结果相同。LRP(+)/MRP(+)与LRP(-)/MRP(-)患者首次完全缓解率的差异有统计学意义（P<0.05）。LRP与MRP基因之间无相关性。
LRP和MRP基因单独作为预测原发性多药耐药的指标均不敏感，但LRP与MRP联合作为一个指标将具有敏感性。
