[转化生长因子-β超家族在新骨形成调节中的作用]
[Transforming growth factor-beta superfamily in the regulation of new bone formation].
作者信息
Li Xin, Huang Xin, Qi Zuo-Liang, Wang Wei
机构信息
Department of Plastic Surgery, Ninth People's Hospital of Shanghai, Second Medical University, Shanghai, P. R. China 200011.
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2002 Mar;16(2):126-9.
OBJECTIVE
To review the recent advances in transforming growth factor-beta(TGF-beta) superfamily study and its role in new bone formation.
METHODS
The latest original articles related to this subject were retrieved extensively, especially the effect of TGF-beta, bone morphogenetic proteins(BMPs) and activin(ACT) on distraction osteogenesis.
RESULTS
TGF-beta, BMPs and ACT play important roles in prompting new bone formation and each of them has different effects. Among them, TGF-beta can stimulate the proliferation of osteoblast and synthesis of extra cellular medium; BMPs can initiate the differentiation of interstitial cell to osteocyte; then ACT displays the combine effect of above two factors.
CONCLUSION
TGF-beta superfamily can regulate new bone formation and thus shorten the course of mandibular distraction osteogenesis.
目的
综述转化生长因子-β（TGF-β）超家族研究的最新进展及其在新骨形成中的作用。
方法
广泛检索与该主题相关的最新原始文章，尤其是TGF-β、骨形态发生蛋白（BMPs）和激活素（ACT）对牵张成骨的影响。
结果
TGF-β、BMPs和ACT在促进新骨形成中起重要作用，且各有不同作用。其中，TGF-β可刺激成骨细胞增殖和细胞外基质合成；BMPs可启动间充质细胞向骨细胞分化；而ACT则表现出上述两种因子的联合作用。
结论
TGF-β超家族可调节新骨形成，从而缩短下颌骨牵张成骨的疗程。
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