Arndt V, Stürmer T, Stegmaier C, Ziegler H, Dhom G, Brenner H
Department of Epidemiology, University of Ulm, D-89081 Ulm, Germany.
Br J Cancer. 2002 Apr 8;86(7):1034-40. doi: 10.1038/sj.bjc.6600209.
Early diagnosis is a tenet in oncology and should enable early treatment with the expectation of improved outcome. Extent and determinants of patient delay of diagnosis in breast cancer patients and its impact on stage of disease were examined in a population based study among female breast cancer patients in Germany. Two hundred and eighty-seven women, aged 18 to 80 years with newly diagnosed invasive symptomatic breast cancer, were interviewed with respect to the diagnostic process. Patient delay was defined as time from onset of first symptoms to first consultation of a doctor. Median patient delay was 16 days among symptomatic patients. Eighteen per cent of all breast cancer patients waited longer than 3 months before consulting a physician. Long patient delay was associated with old age, history of a benign mastopathy, obesity, and indices of health behaviour such as not knowing a gynaecologist for out-patient care and non-participation in general health screening examinations. A strong association between patient delay and stage at diagnosis was observed for poorly differentiated tumours. These results suggest that at risk groups for delaying consultation can be identified and that a substantial proportion of late stage diagnoses of poorly differentiated breast cancer cases could be avoided if all patients with breast cancer symptoms would present to a doctor within 1 month.
早期诊断是肿瘤学的一项原则,应能实现早期治疗,以期改善预后。在德国一项针对女性乳腺癌患者的基于人群的研究中,对乳腺癌患者诊断延迟的程度、决定因素及其对疾病分期的影响进行了研究。对287名年龄在18至80岁之间、新诊断为有症状浸润性乳腺癌的女性进行了关于诊断过程的访谈。患者延迟被定义为从首次症状出现到首次咨询医生的时间。有症状患者的中位患者延迟为16天。所有乳腺癌患者中有18%在咨询医生之前等待了超过3个月。患者延迟时间长与老年、良性乳腺病病史、肥胖以及健康行为指标有关,如不认识妇科门诊医生和不参加一般健康筛查检查。对于低分化肿瘤,观察到患者延迟与诊断时的分期之间存在密切关联。这些结果表明,可以识别出延迟咨询的风险群体,并且如果所有有乳腺癌症状的患者能在1个月内就诊,相当一部分低分化乳腺癌病例的晚期诊断是可以避免的。