[猫大脑体感Ⅰ区内脏伤害性神经元的细胞内电生理特性]

[Intracellular electrophysiological characteristics of visceral nociceptive neurons in cortex S I area of cats].

作者信息

Chen J H, Teng G X

机构信息

Laboratory of Neurophysiology, Brain Research Institute, China Medical University, Shenyang 110001.

出版信息

Sheng Li Xue Bao. 1999 Feb;51(1):31-7.

PMID:11972172

Abstract

In the present work we investigated electrophysiological properties of visceral nociceptive neurons in the primary somatosensory cortex (SI). Intracellular recordings of 851 neurons in the representing area of greater splanchnic nerve (GSN) in SI area were made in 22 cats. The neurons showed a variety of modes in spontaneous discharges, which could be classified into visceral nociceptive neurons (VNNs) and non-visceral nociceptive neurons (NVNNs). VNNs (412) could be further divided into specific and non-specific subtypes, with three distinct response modes: excitatory, inhibitory, and mixed response. These responses were characterized by longer latency and complex responsive fashion. In addition, 85 single convergence neurons induced by input from GSN and intercostal nerve were observed. Neurobiotin was injected into some of the cells by electrophoresis to identify the depth and morphology following recordings. The results indicated that VNNs were located in the SI area.

摘要

在本研究中，我们调查了初级体感皮层（SI）中内脏伤害性神经元的电生理特性。在22只猫中，对SI区内脏大神经（GSN）代表区域的851个神经元进行了细胞内记录。这些神经元在自发放电中表现出多种模式，可分为内脏伤害性神经元（VNNs）和非内脏伤害性神经元（NVNNs）。VNNs（412个）可进一步分为特异性和非特异性亚型，具有三种不同的反应模式：兴奋性、抑制性和混合反应。这些反应的特点是潜伏期较长且反应方式复杂。此外，观察到由GSN和肋间神经输入诱导的85个单会聚神经元。记录后，通过电泳将神经生物素注入一些细胞中，以确定其深度和形态。结果表明，VNNs位于SI区。