Jurado M A, Junqué C, Vallejo J, Salgado P, Grafman J
Dpt. Psiquiatria i Psicobiologia clínica, Universitat de Barcelona, Spain.
J Clin Exp Neuropsychol. 2002 May;24(3):261-9. doi: 10.1076/jcen.24.3.261.986.
Obsessive-compulsive disorder (OCD) has been related to frontostriatal dysfunction, but some inconsistencies between studies and a relative paucity of neuropsychological research still characterizes the study of OCD. We compared 28 patients with OCD and matched healthy controls on two neuropsychological tests sensitive to frontal dysfunction: temporal ordering and a "feeling-of-doing" (FOD) judgment about ordering. The OCD group performed significantly worse than controls in the temporal ordering task despite showing normal recognition memory. Patients were also impaired in "feeling-of-doing" judgments suggesting they have a lack of self-awareness of their performance. Thus, the results of the current study reinforces previous research that indicates that OCD patients fail on tasks that require adequate functioning of the frontal-striatal pathways.