胺碘酮诱发的抗利尿激素分泌不当综合征（SIADH）：两例报告
Syndrome of inappropriate antidiuretic hormone secretion (SIADH) induced by amiodarone: a report on two cases.
作者信息
Ikegami Haruhiko, Shiga Tsuyoshi, Tsushima Toshio, Nirei Takashi, Kasanuki Hiroshi
机构信息
Department of Cardiology, The Heart Institute of Japan, Tokyo Women's Medical University, Shinjuku, Tokyo, Japan.
出版信息
J Cardiovasc Pharmacol Ther. 2002 Jan;7(1):25-8. doi: 10.1177/107424840200700i104.
BACKGROUND
Amiodarone is an effective antiarrhythmic agent for life-threatening arrhythmias but has some noncardiac toxicity. The syndrome of inappropriate antidiuretic hormone secretion (SIADH) induced by amiodarone during long-term therapy seems to be rare among adverse effects.
SUBJECTS AND RESULTS
We report on two elderly cases that developed hyponatremia caused by SIADH occurring during the initial loading period of amiodarone therapy. Both cases improved within 3 weeks after reduction of the dose, although amiodarone was continued.
CONCLUSIONS
Amiodarone-induced SIADH may occur during the initial loading period, and it may be improved by reduction of the dose without discontinuation of the drug.
背景
胺碘酮是治疗危及生命的心律失常的有效抗心律失常药物，但具有一些非心脏毒性。长期治疗期间胺碘酮诱发的抗利尿激素分泌不当综合征（SIADH）在不良反应中似乎较为罕见。
研究对象与结果
我们报告两例老年患者，在胺碘酮治疗的初始负荷期发生SIADH导致低钠血症。尽管继续使用胺碘酮，但两例患者在剂量减少后3周内均有改善。
结论
胺碘酮诱发的SIADH可能在初始负荷期发生，且可通过减少剂量而不停药来改善。
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