接受生长激素治疗的HIV-1感染成年患者胸腺质量增加及循环中初始CD4 T细胞增多。
Increased thymic mass and circulating naive CD4 T cells in HIV-1-infected adults treated with growth hormone.
作者信息
Napolitano Laura A, Lo Joan C, Gotway Michael B, Mulligan Kathleen, Barbour Jason D, Schmidt Diane, Grant Robert M, Halvorsen Robert A, Schambelan Morris, McCune Joseph M
机构信息
Gladstone Institute of Virology and Immunology, University of California at San Francisco, San Francisco, CA 94141, USA.
出版信息
AIDS. 2002 May 24;16(8):1103-11. doi: 10.1097/00002030-200205240-00003.
OBJECTIVE
To determine whether treatment with growth hormone (GH) enhances thymopoiesis in individuals infected with HIV-1.
METHODS
Five HIV-1-infected adults were treated with GH for 6-12 months in a prospective open-label study. Immunological analyses were performed before GH treatment and repeated at 3 month intervals after GH initiation. Thymic mass was analysed using computed tomography with quantitative density and volume analysis. Analysis of circulating lymphocytes, including naive and memory T cell subsets, was performed using multiparameter flow cytometry.
RESULTS
GH treatment was associated with a marked increase in thymic mass in all GH recipients. Circulating naive CD4 T cells also increased significantly in all patients during GH therapy, suggesting an enhancement of thymopoiesis.
CONCLUSION
GH has significant effects on the human immune system, including the reversal of thymic atrophy in HIV-1-infected adults. De-novo T cell production may thus be inducible in immunodeficient adults.
目的
确定生长激素（GH）治疗是否能增强HIV-1感染者的胸腺生成。
方法
在一项前瞻性开放标签研究中，对5名HIV-1感染的成年人进行了6至12个月的GH治疗。在GH治疗前进行免疫分析，并在开始GH治疗后每隔3个月重复进行。使用计算机断层扫描进行胸腺质量分析，并进行定量密度和体积分析。使用多参数流式细胞术对循环淋巴细胞进行分析，包括初始和记忆T细胞亚群。
结果
在所有接受GH治疗的患者中，GH治疗与胸腺质量显著增加有关。在GH治疗期间，所有患者循环中的初始CD4 T细胞也显著增加，提示胸腺生成增强。
结论
GH对人体免疫系统有显著影响，包括逆转HIV-1感染成年人的胸腺萎缩。因此，在免疫缺陷的成年人中可能诱导产生新生T细胞。
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