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妊娠期溃疡性结肠炎的治疗(作者译)

[Treatment of colitis ulcerosa during pregnancy (author's transl)].

作者信息

Dame W R, Karoff J C, Wagner H

出版信息

Z Geburtshilfe Perinatol. 1979 Aug;183(4):307-10.

PMID:120087
Abstract

Aggressive pharmacotherapeutic and surgical measures are often contra-indicated in the treatment of colitis ulcerosa in pregnancy. Especially in the sensitive embryonal development phase, the use of antibiotics, anti-inflammatory drugs, chemotherapeutics and ACTH is considered questionable. The subtotal colectomies and ileostomies often demanded in toxically dramatic colitides place a considerable burden on mother and foetus. A conservative therapeutic regimen, which has been successfully used in more than 80 patients with inflammatory intestinal diseases, was modified to suit the requirements of pregnancy. This is a combination therapy involving parenteral feeding, food which can be absorbed by the intestinal walls, and a suitably adapted pharmacotherapy. In one case of a severe toxic relapse of colitis ulcerosa during early pregnancy, remission was achieved in a patient while fully maintaining the pregnancy.

摘要

积极的药物治疗和手术措施在妊娠期溃疡性结肠炎的治疗中往往是禁忌的。特别是在敏感的胚胎发育阶段,使用抗生素、抗炎药、化疗药物和促肾上腺皮质激素被认为存在问题。在毒性剧烈的结肠炎中经常需要进行的次全结肠切除术和回肠造口术给母亲和胎儿带来了相当大的负担。一种已成功应用于80多名炎症性肠病患者的保守治疗方案被修改以适应妊娠的需求。这是一种联合治疗,包括肠外营养、可被肠壁吸收的食物以及适当调整的药物治疗。在一例妊娠早期溃疡性结肠炎严重毒性复发的病例中,一名患者实现了缓解,同时完全维持了妊娠。

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