Tuck A B, Chambers A F
Department of Oncology, University of Western Ontario, London, Canada.
J Mammary Gland Biol Neoplasia. 2001 Oct;6(4):419-29. doi: 10.1023/a:1014734930781.
Osteopontin (OPN) is a secreted, integrin-binding protein which has been implicated in cancer, as well as other pathologies and some aspects of normal development. Here we focus on the role of OPN in breast cancer. We describe studies that have shown that OPN plays a role in normal mammary gland development as well as in progression of breast cancer. We also summarize studies that have shown that OPN can play a functional role in malignancy of breast cancer. At least some of these effects are mediated by specific cell surface integrins (alpha(v)beta3 vs. alpha(v)beta1 and alpha(v)beta5) and lead to increased cell migration, activation of growth factor/receptor pathways (e.g. HGF and EGF), and increased proteolytic enzyme activity (e.g. uPA). We also summarize clinical studies that show that OPN levels in tumors and blood are elevated in women with metastatic breast cancer and may offer promise as prognostic markers in breast cancer.
骨桥蛋白（OPN）是一种分泌型整合素结合蛋白，与癌症以及其他病理状况和正常发育的某些方面有关。在此我们聚焦于OPN在乳腺癌中的作用。我们描述了一些研究，这些研究表明OPN在正常乳腺发育以及乳腺癌进展中发挥作用。我们还总结了一些研究，这些研究表明OPN在乳腺癌恶性肿瘤中可发挥功能作用。这些效应中至少有一些是由特定的细胞表面整合素（α(v)β3与α(v)β1和α(v)β5）介导的，会导致细胞迁移增加、生长因子/受体途径（如HGF和EGF）激活以及蛋白水解酶活性（如uPA）增加。我们还总结了临床研究，这些研究表明转移性乳腺癌女性患者肿瘤和血液中的OPN水平升高，并且可能有望作为乳腺癌的预后标志物。
