Matĕjková E
Folia Biol (Praha). 1975;21(5):349-53.
Changes in the leucocytes, lymphocytes and peripheral blood lymphocyte nucleoli of Yoshida ascitic sarcoma bearing rats untreated and treated with cyclophosphamide were studied. In the course of the growth of Yoshida ascitic sarcoma lymphocytes with "active" nucleoli (compact nucleoli and nucleoli with nucleolonemas) first increased and then, in the terminal stage of the disease, decreased in number. The number of lymphocytes with ring-shaped nucleoli ("reversibly inactive") and micronucleoli was rising throughout the disease. The increase in numbers of micronucleoli in the lymphocytes produced increased values of nucleolar coefficient. After administration of cyclophosphamide to rats with transplanted tumour the number of lymphocytes with both "active" and "reversibly inactive" nucleoli decreased and the number of lymphocytes with micronucleoli increased. The increase in the proportion of micronucleoli also led to increased values of nucleolar coefficient. After cessation of cyclophosphamide treatment and when the signs of the neoplastic disease had disappeared, the changes observed in the white blood cell picture returned to the values before sarcoma transplantation.
对未治疗及经环磷酰胺治疗的吉田腹水肉瘤荷瘤大鼠的白细胞、淋巴细胞及外周血淋巴细胞核仁变化进行了研究。在吉田腹水肉瘤生长过程中，具有“活跃”核仁（致密核仁及带有核仁丝的核仁）的淋巴细胞数量先增加，然后在疾病末期减少。具有环形核仁（“可逆性无活性”）和微核仁的淋巴细胞数量在整个疾病过程中不断上升。淋巴细胞中微核仁数量的增加导致核仁系数值升高。给移植肿瘤的大鼠施用环磷酰胺后，具有“活跃”和“可逆性无活性”核仁的淋巴细胞数量减少，而具有微核仁的淋巴细胞数量增加。微核仁比例的增加也导致核仁系数值升高。停止环磷酰胺治疗且肿瘤疾病体征消失后，白细胞图像中观察到的变化恢复到肉瘤移植前的值。
