Simon P, Jung G-M, Bonnomet F, Babin S-R
Service de Traumatologie, Hôpital de Hautepierre, avenue Molière, 67098 Strasbourg Cedex, France.
Rev Chir Orthop Reparatrice Appar Mot. 2002 May;88(3):271-8.
Post-radiation shaft fractures of long bones are uncommon. Late or partial healing increases the risk of stress fracture. Different fixation techniques have been proposed. Treatment of radiated bone is difficult. We report a series of 6 nonunions of the proximal femur after radiotherapy.
Three patients had true fractures of irradiated bones several years after radiotherapy for bone or soft tissue tumors. Three other patients had pathological fractures or malignant osteolysis related to a myeloma and treated by osteosynthesis and post-operative radiotherapy.
Treatment required a total of 19 surgical procedures. There were nine stress fractures of ostheosynthesis material involving locked nails, cervicodiaphyseal nails and plates. There were no vascularized grafts in this series. At last follow-up the pathological fracture had healed in three cases, was stable but not healed in two, and required prosthetic reconstruction in one.
We emphasize the importance of rigorous patient selection for radiotherapy and the possible preventive effect of osteosynthesis in certain cases with a high risk of secondary fracture of an irradiated bone. Vascularized grafts may be useful for refractory nonunion and may be proposed as first line treatment for post-radiation fractures.
长骨放疗后骨干骨折并不常见。延迟愈合或部分愈合会增加应力性骨折的风险。人们提出了不同的固定技术。放疗后骨的治疗很困难。我们报告了一系列6例股骨近端放疗后骨不连的病例。
3例患者在因骨或软组织肿瘤接受放疗数年之后出现了放疗骨的真性骨折。另外3例患者发生了与骨髓瘤相关的病理性骨折或恶性骨质溶解,并接受了骨固定术及术后放疗。
治疗共需要19次外科手术。有9例骨固定材料出现应力性骨折,涉及锁定髓内钉、经颈骨干髓内钉和钢板。本系列中未采用带血管蒂移植物。在最后一次随访时,3例病理性骨折已愈合,2例病情稳定但未愈合,1例需要进行假体重建。
我们强调放疗时严格选择患者的重要性,以及在某些 irradiated bone继发骨折风险较高的病例中骨固定术可能具有的预防作用。带血管蒂移植物可能对难治性骨不连有用,可作为放疗后骨折的一线治疗方法。