Pratt Julian R, Basheer Shamim A, Sacks Steven H
Department of Nephrology & Transplantation, King's College University of London, Guy's Hospital, London, UK.
Nat Med. 2002 Jun;8(6):582-7. doi: 10.1038/nm0602-582.
Accumulating evidence suggests that innate immunity interacts with the adaptive immune system to identify potentially harmful antigens and eliminate them from the host. A central facet of innate immunity is complement, which for some time has been recognized as a contributor to inflammation in transplant rejection but without detailed analysis of its role in what is principally a T cell mediated process. Moreover, epithelial and vascular tissues at local sites of inflammation secrete complement components; however, the role of such local synthesis remains unclear. Here we show that the absence of locally synthesized complement component C3 is capable of modulating the rejection of renal allografts in vivo and regulating T-cell responses in vivo and in vitro. The results indicate that improved success in kidney transplantation could come from therapeutic manipulation of innate immunity in concert with T cell directed immunosuppression.
越来越多的证据表明，先天免疫与适应性免疫系统相互作用，以识别潜在有害抗原并将其从宿主体内清除。先天免疫的一个核心方面是补体，一段时间以来，补体一直被认为是移植排斥反应中炎症的一个促成因素，但尚未对其在主要由T细胞介导的过程中的作用进行详细分析。此外，炎症局部部位的上皮和血管组织会分泌补体成分；然而，这种局部合成的作用仍不清楚。在这里，我们表明，局部合成的补体成分C3的缺失能够在体内调节肾移植的排斥反应，并在体内和体外调节T细胞反应。结果表明，肾移植成功率的提高可能来自于先天免疫的治疗性调控与针对T细胞的免疫抑制协同作用。
