潜伏性转化生长因子-β结合蛋白-3（LTBP-3）需要与转化生长因子-β结合才能分泌。
Latent TGF-beta binding protein-3 (LTBP-3) requires binding to TGF-beta for secretion.
作者信息
Chen Yan, Dabovic Branka, Annes Justin P, Rifkin Daniel B
机构信息
Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA.
出版信息
FEBS Lett. 2002 Apr 24;517(1-3):277-80. doi: 10.1016/s0014-5793(02)02648-0.
Latent transforming growth factor-beta (TGF-beta) binding protein (LTBP)-1, which is easily secreted, has been shown to enhance the secretion of TGF-beta. Here we show that another member of the LTBP family, LTBP-3, is not secreted by several cell types, but secretion occurs after coexpression with TGF-beta. The secretion of LTBP-3 requires complexing of LTBP-3 with Cys33 of the TGF-beta propeptide.
潜在转化生长因子-β（TGF-β）结合蛋白（LTBP）-1易于分泌，已被证明可增强TGF-β的分泌。在此我们表明，LTBP家族的另一个成员LTBP-3，在几种细胞类型中并不分泌，但与TGF-β共表达后会发生分泌。LTBP-3的分泌需要LTBP-3与TGF-β前肽的Cys33形成复合物。
Zotero 插件