母体缺氧时胎儿氧合的功能磁共振成像（fMRI）：初步结果
Functional magnetic resonance imaging (fMRI) for fetal oxygenation during maternal hypoxia: initial results.
作者信息
Wedegärtner U, Tchirikov M, Koch M, Adam G, Schröder H
机构信息
Abteilung für Diagnostische und Interventionelle Radiologie, Klinik und Poliklinik für Radiologie, UKE Hamburg, Germany.
出版信息
Rofo. 2002 Jun;174(6):700-3. doi: 10.1055/s-2002-32222.
PURPOSE
To investigate the potential of fMRI to measure changes in fetal tissue oxygenation during acute maternal hypoxia in fetal lambs.
MATERIAL AND METHODS
Two ewes carrying singleton fetuses (gestational age 125 and 131 days) underwent MR imaging under inhalation anesthesia. BOLD imaging of the fetal brain, liver and myocardium was performed during acute maternal hypoxia (oxygen replaced by N 2 O). Maternal oxygen saturation and heart rate were monitored by a pulse-oxymeter attached to the maternal tongue.
RESULTS
Changes of fetal tissue oxygenation during maternal hypoxia were clearly visible with BOLD MRI. Signal intensity decreases were more distinct in liver and heart ( approximately 40 %) from control than in the fetal brain ( approximately 10 %).
CONCLUSIONS
fMRI is a promising diagnostic tool to determine fetal tissue oxygenation and may open new opportunities in monitoring fetal well being in high risk pregnancies complicated by uteroplacentar insufficiency. Different signal changes in liver/heart and brain may reflect a centralization of the fetal blood flow.
目的
研究功能磁共振成像（fMRI）测量胎羊急性母体缺氧期间胎儿组织氧合变化的潜力。
材料与方法
两只怀有单胎胎儿（孕龄分别为125天和131天）的母羊在吸入麻醉下接受磁共振成像检查。在急性母体缺氧（氧气被一氧化二氮替代）期间对胎儿脑、肝和心肌进行血氧水平依赖性功能磁共振成像（BOLD成像）。通过连接在母羊舌头上的脉搏血氧仪监测母体血氧饱和度和心率。
结果
利用BOLD磁共振成像清晰可见母体缺氧期间胎儿组织氧合的变化。与对照组相比，肝脏和心脏的信号强度下降更为明显（约40%），而胎儿脑内的信号强度下降约为10%。
结论
fMRI是一种很有前景的诊断工具，可用于确定胎儿组织氧合情况，并可能为监测合并子宫胎盘功能不全的高危妊娠中胎儿的健康状况带来新机遇。肝脏/心脏和脑内不同的信号变化可能反映了胎儿血流的集中化。
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