Feltmate Colleen M, Genest David R, Goldstein Donald P, Berkowitz Ross S
Gillette Center for Women's Cancers, Department of Pathology, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
J Reprod Med. 2002 May;47(5):337-41.
Placental site trophoblastic tumor (PSTT) is the least common form of gestational trophoblastic disease. The tumor represents a neoplastic transformation of intermediate trophoblastic cells that normally play a critical role in implantation. PSTT can occur after a normal pregnancy, spontaneous abortion, termination of pregnancy, ectopic pregnancy or molar pregnancy. It displays a wide spectrum of behavior, and when metastatic, can be difficult to control even with surgery and chemotherapy. Because of PSTT's rarity, limited information is known about its natural history. Several recent studies have indicated that mitotic index is an important prognostic indicator. Advances in chemotherapeutic regimens have also improved clinical response in metastatic disease.
胎盘部位滋养细胞肿瘤（PSTT）是妊娠滋养细胞疾病最不常见的形式。该肿瘤代表中间型滋养细胞的肿瘤性转化，这些细胞通常在着床过程中起关键作用。PSTT可发生于正常妊娠、自然流产、人工流产、异位妊娠或葡萄胎妊娠之后。它表现出广泛的行为特征，发生转移时，即使采用手术和化疗也难以控制。由于PSTT罕见，关于其自然病史的信息有限。最近的几项研究表明，有丝分裂指数是一个重要的预后指标。化疗方案的进展也改善了转移性疾病的临床反应。
