Bergé Stefaan J, Plath Hanno, von Lindern Jens J, Appel Thorsten, Niederhagen Bernd, Van de Vondel Patricia T, Hansmann Manfred
Department of Oral and Maxillofacial Surgery, Division of Prenatal Diagnosis and Therapy, Friedrich Wilhelm University, Sigmund-Freud-Strasse 25, D-53105 Bonn, Germany.
Fetal Diagn Ther. 2002 Jul-Aug;17(4):247-51. doi: 10.1159/000063402.
This study is an analysis of neonatal outcome in 70 fetuses diagnosed over a 10-year period as having cleft lip with or without cleft palate (CL-P) by ultrasonographic examination.
We describe the natural history of these 70 fetuses with orofacial clefts and select those who may be candidates for fetal surgery. The sonograms of 70 fetuses with orofacial clefts were evaluated for the nature of the CL-P and for the nature of the associated anomalies. Additionally, karyotyping was performed in 63 of 70 patients (90%).
The frequency of additional anomalies and the mortality rate varied with the type of cleft. Also, the frequency and type of chromosomal abnormalities varied with the type of cleft. The overall mortality rate was 63% (n = 44). 3 of the surviving 26 fetuses had severe associated anomalies. In 13 of the remaining 23 cases, the fetal age at diagnosis (> or =22 weeks) excluded the fetuses from the potential benefits of fetal intervention.
Of 70 fetuses with prenatally diagnosed orofacial clefts, only 10 (14%) were candidates for fetal CL-P surgery.
本研究分析了在10年期间经超声检查诊断为唇裂伴或不伴腭裂（CL-P）的70例胎儿的新生儿结局。
我们描述了这70例口面部裂胎儿的自然病史，并筛选出可能适合胎儿手术的病例。对70例口面部裂胎儿的超声图像进行评估，以确定CL-P的性质及相关异常的性质。此外，70例患者中的63例（90%）进行了染色体核型分析。
额外异常的发生率和死亡率因腭裂类型而异。同样，染色体异常的频率和类型也因腭裂类型而异。总体死亡率为63%（n = 44）。存活的26例胎儿中有3例伴有严重相关异常。在其余23例中的13例中，诊断时的胎儿孕周（≥22周）使胎儿无法从胎儿干预中获益。
在70例产前诊断为口面部裂的胎儿中，只有10例（14%）适合进行胎儿CL-P手术。
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