González Galilea A, García Sánchez M V, la Mata García M, Miño Fugarolas G
Unidad Clínica de Aparato Digestivo, Hospital Universitario Reina Sofía, Córdoba, Spain.
Gastroenterol Hepatol. 2002 Jun-Jul;25(6):392-4.
Amiodarone is a widely used and effective long-term antiarrhythmic drug but with known adverse effects. Prolonged oral administration of this drug has been implicated in numerous hepatic lesions, ranging from isolated, asymptomatic transaminase elevation to fulminant, fatal liver failure. Few cases of acute hepatotoxicity due to intravenous administration have been reported. We present a 69-year-old woman with atrial fibrillation who developed acute hepatitis within 24 hours of amiodarone infusion at the recommended dosage. The drug was withdrawn and laboratory findings progressively returned to normal over the following days. We analyze a possible mechanism of action for hepatotoxicity and highlight the importance of monitoring liver function in patients receiving this drug.
胺碘酮是一种广泛使用且有效的长期抗心律失常药物，但存在已知的不良反应。长期口服该药物与众多肝脏病变有关，范围从孤立的、无症状的转氨酶升高到暴发性、致命性肝衰竭。静脉给药导致急性肝毒性的病例报道较少。我们报告一名69岁的房颤女性患者，在以推荐剂量输注胺碘酮后24小时内发生急性肝炎。药物停用后，实验室检查结果在接下来的几天逐渐恢复正常。我们分析了肝毒性可能的作用机制，并强调了在接受该药物治疗的患者中监测肝功能的重要性。
