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[分化型甲状腺癌全甲状腺切除术后通过改变甲状腺激素剂量评估可靠的垂体抑制疗法]

[Evaluation of reliable pituitary suppression therapy through varying thyroid hormone dosage following total thyroidectomy due to a differentiated thyroid carcinoma].

作者信息

Wahl R, Hüfner M, Röher H D, Papke W

出版信息

Langenbecks Arch Chir. 1975;Suppl:469-74.

PMID:1207280
Abstract

The reliability of pituitary suppression by administration of 1-thyroxin (t4) or a combination of thyroxin and triiodothyronin (t3) of variable dosage following radical surgery for thyroid cancer in 13 patients was investigated by means of TRH-test and measurement of serum hormone levels. In contrary to generally applied higher doses the results were able to demonstrate that 0.2 to 0.3 mg 1-thyroxin is a sufficient dosage for a complete suppression of TSH-stimulation. In the presence of obviously more side effects the treatment with a combination of t4 and t3 is not of any advantage.

摘要

通过促甲状腺激素释放激素(TRH)试验和血清激素水平测定,对13例甲状腺癌根治术后患者给予不同剂量的1 - 甲状腺素(T4)或甲状腺素与三碘甲状腺原氨酸(T3)联合用药抑制垂体功能的可靠性进行了研究。与普遍应用的较高剂量相反,结果表明0.2至0.3毫克1 - 甲状腺素足以完全抑制促甲状腺激素(TSH)的刺激。在明显存在更多副作用的情况下,T4和T3联合治疗没有任何优势。

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