Wahl R, Hüfner M, Röher H D, Papke W
Langenbecks Arch Chir. 1975;Suppl:469-74.
The reliability of pituitary suppression by administration of 1-thyroxin (t4) or a combination of thyroxin and triiodothyronin (t3) of variable dosage following radical surgery for thyroid cancer in 13 patients was investigated by means of TRH-test and measurement of serum hormone levels. In contrary to generally applied higher doses the results were able to demonstrate that 0.2 to 0.3 mg 1-thyroxin is a sufficient dosage for a complete suppression of TSH-stimulation. In the presence of obviously more side effects the treatment with a combination of t4 and t3 is not of any advantage.
通过促甲状腺激素释放激素(TRH)试验和血清激素水平测定,对13例甲状腺癌根治术后患者给予不同剂量的1 - 甲状腺素(T4)或甲状腺素与三碘甲状腺原氨酸(T3)联合用药抑制垂体功能的可靠性进行了研究。与普遍应用的较高剂量相反,结果表明0.2至0.3毫克1 - 甲状腺素足以完全抑制促甲状腺激素(TSH)的刺激。在明显存在更多副作用的情况下,T4和T3联合治疗没有任何优势。