L-5-羟色氨酸诱导惊恐障碍患者和健康志愿者唾液皮质醇增加。
L-5-hydroxytryptophan induced increase in salivary cortisol in panic disorder patients and healthy volunteers.
作者信息
Schruers Koen, van Diest Rob, Nicolson Nancy, Griez Eric
机构信息
Department of Psychiatry, Institute of Brain and Behaviour, Maastricht University, P.O. Box 88, 6200 AB Maastricht The Netherlands,
出版信息
Psychopharmacology (Berl). 2002 Jun;161(4):365-9. doi: 10.1007/s00213-002-1072-8. Epub 2002 Apr 19.
BACKGROUND
Hypersensitivity of brain serotonin receptors has been proposed as a causal mechanism in the pathophysiology of panic disorder. This theory can be tested, using serotonergic stimulation of the HPA axis. Up to now, plasma cortisol has generally been used as the outcome measure in such studies. Assessment of salivary cortisol is a non-invasive alternative to measure HPA axis activity.
METHOD
Salivary cortisol levels were measured in 24 panic disorder patients and 24 healthy volunteers, following ingestion of 200 mg L-5-hydroxytryptophan or placebo.
RESULTS
A significant rise in cortisol was observed in both patients and controls following ingestion of L-5-hydroxytryptophan. No such effects were seen in the placebo condition.
CONCLUSION
The results show that L-5-hydroxytryptophan stimulated salivary cortisol is a useful probe of serotonin function in healthy volunteers as well as panic disorder patients, and provide some evidence against a serotonin receptor hypersensitivity in panic disorder.
背景
脑血清素受体超敏反应被认为是惊恐障碍病理生理学中的一种因果机制。该理论可用血清素对下丘脑-垂体-肾上腺（HPA）轴的刺激来进行检验。到目前为止，此类研究中通常将血浆皮质醇用作结果指标。唾液皮质醇评估是测量HPA轴活性的一种非侵入性替代方法。
方法
在24名惊恐障碍患者和24名健康志愿者摄入200毫克L-5-羟色氨酸或安慰剂后，测量他们的唾液皮质醇水平。
结果
摄入L-5-羟色氨酸后，患者和对照组的皮质醇均显著升高。在安慰剂组未观察到此类效应。
结论
结果表明，L-5-羟色氨酸刺激唾液皮质醇是健康志愿者和惊恐障碍患者血清素功能的有用检测指标，并为反对惊恐障碍中血清素受体超敏反应提供了一些证据。
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