Ferron François, Longhi Sonia, Henrissat Bernard, Canard Bruno
Architecture et Fonction des Macromolécules Biologiques, UMR 6098, CNRS, and Universitées Aix-Marseille I and II, ESIL, 163, Avenue de Luminy, Case 925, F-13288 Marseille Cedex 9, France.
Trends Biochem Sci. 2002 May;27(5):222-4. doi: 10.1016/s0968-0004(02)02091-1.
The Mononegavirales virus group comprises several major human pathogens, including measles, rabies and Ebola viruses. This article reports a computational analysis of the C-terminal region of RNA-dependent RNA-polymerases from Mononegavirales. Using a combination of sequence similarity and threading analysis, a 2'-O-ribose methyltransferase domain was identified that is involved in the capping of viral mRNAs.
单股负链RNA病毒目病毒组包含几种主要的人类病原体，包括麻疹病毒、狂犬病病毒和埃博拉病毒。本文报道了对单股负链RNA病毒目病毒的RNA依赖性RNA聚合酶C末端区域的计算分析。通过结合序列相似性和穿线分析，鉴定出一个参与病毒mRNA加帽的2'-O-核糖甲基转移酶结构域。
Zotero 插件