[Cross-protection against Schistosoma japonicum infection in mice immunized with Trichinella spiralis muscle larva antigen].

AIM

To explore the cross-protection against S. japonicum cercaria challenge in mice immunized with T. spiralis larva antigen.

METHODS

Groups of BALB/c mice were immunized with 4 preparations of T. spiralis larva antigen, respectively. Vaccinated mice were then challenged with 30 and 100 S. japonicum cercariae, respectively. Forty-five days later, all mice were sacrificed and examined for adult worm burden, liver and stool egg count.

RESULTS

All groups of mice immunized with 4 preparations of T. spiralis larvae antigen without adjuvant showed significant protection against S. japonicum. Among these antigen preparations, the soluble antigen (TsLSA) presented highest protection with reductions in worm burden and liver and stool egg counts of 21.3%, 48.0% and 58.5%, respectively. When mice were immunized with TsLSA plus Freunds complete adjuvant (FCA) or with double-dose of the antigen, the worm reduction rate was increased to 29.3% and 39.6%, respectively.

CONCLUSION

Different preparations of T. spiralis muscle larva antigen could induce protection against S. japonicum in mice.