Krüger Stefan, Brandenburg Vincent M, Hoffmann Rainer, Breuer Christian, Riehl Jochen
Medizinische Klinik I, Universitätsklinikum Rheinisch-Westfälische Technische Hochschule Aachen.
Med Klin (Munich). 2002 May 15;97(5):304-7. doi: 10.1007/s00063-002-1158-4.
Pulmonary alveolar microlithiasis is a rare disease, which is characterized by pulmonary deposition of calcium phosphate microliths. The radiographic features can be pathognomonic with a "sandstorm"-like opacification throughout the lungs.
A 29-year-old Moroccan presented for the first time 1988 with atypical chest pain. His history was characterized by nephrocalcinosis and pulmonary disease. Physical examination and laboratory values were unremarkable. Chest X-ray revealed extensive bilateral pulmonary infiltrates with "sandstorm"-like opacifications. Sonography showed medullary nephrocalcinosis. The diagnosis of pulmonary alveolar microlithiasis was confirmed by transbronchial biopsy. Over the next 13 years there was only a moderate expansion of the pulmonary infiltrates and a beginning restrictive pattern, whereas the patient was almost symptom-free.
Pulmonary alveolar microlithiasis is a rare cause of bilateral pulmonary infiltrates and should be considered in the differential diagnosis. In some cases there is also an association with calcifications of extrapulmonary organs.
肺泡微石症是一种罕见疾病,其特征为磷酸钙微结石在肺内沉积。影像学表现具有特征性,整个肺部呈现“沙尘暴”样的不透光区。
一名29岁的摩洛哥人于1988年首次因非典型胸痛就诊。其病史以肾钙质沉着症和肺部疾病为特征。体格检查和实验室检查结果均无异常。胸部X线显示双侧肺部广泛浸润,呈“沙尘暴”样不透光区。超声检查显示髓质肾钙质沉着症。经支气管活检确诊为肺泡微石症。在接下来的13年里,肺部浸润仅适度扩大,并开始出现限制性模式,而患者几乎没有症状。
肺泡微石症是双侧肺部浸润的罕见病因,在鉴别诊断中应予以考虑。在某些情况下,它还与肺外器官钙化有关。