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[褪黑素治疗一名患有严重睡眠障碍的盲童]

[Melatonin treatment of a blind child with serious sleep disorders].

作者信息

Ramstad Kjersti, Loge Jon Håvard

机构信息

Barneavdelingen, seksjon for habilitering Akershus universitetssykehus 1474 Nordbyhagen.

出版信息

Tidsskr Nor Laegeforen. 2002 Apr 20;122(10):1005-6.

Abstract

BACKGROUND

Children with developmental and neurological disabilities are prone to develop serious sleep-wake cycle disorders that may be difficult to treat.

MATERIAL AND METHODS

Case history.

RESULTS

A 5-year old blind boy with multiple disabilities developed a chronic sleep-wake cycle disorder as his main clinical problem. Treatment included introduction of strict sleep habits and strengthening of environmental "zeitgebers". After five months melatonin 3 mg was administered at night for 4 weeks. The observation period also included 3 weeks without melatonin. Sleep was registered prospectively by a sleep diary. Strict sleep habits combined with strengthening of "zeitgebers" partially improved the sleep problems, but did not establish a normal sleep pattern. When melatonin was added, he normalized his sleep pattern in a few days. His sleep problems returned during the weeks in which he did not receive melatonin. No side effects were observed.

INTERPRETATION

Melatonin is a promising treatment alternative for serious sleep problems in blind children.

摘要

背景

发育和神经功能障碍的儿童容易出现严重的睡眠-觉醒周期紊乱,且可能难以治疗。

材料与方法

病例史。

结果

一名患有多种残疾的5岁盲童出现慢性睡眠-觉醒周期紊乱作为其主要临床问题。治疗措施包括建立严格的睡眠习惯以及强化环境“时间信号”。五个月后,每晚服用3毫克褪黑素,持续4周。观察期还包括3周不服褪黑素。通过睡眠日记前瞻性记录睡眠情况。严格的睡眠习惯与强化“时间信号”相结合部分改善了睡眠问题,但未建立正常睡眠模式。添加褪黑素后,他在几天内睡眠模式恢复正常。在未服用褪黑素的几周里,他的睡眠问题又复发了。未观察到副作用。

解读

褪黑素是治疗盲童严重睡眠问题的一种有前景的替代疗法。

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