Suppr超能文献

猴痘病毒基因组分析。

Analysis of the monkeypox virus genome.

作者信息

Shchelkunov S N, Totmenin A V, Safronov P F, Mikheev M V, Gutorov V V, Ryazankina O I, Petrov N A, Babkin I V, Uvarova E A, Sandakhchiev L S, Sisler J R, Esposito J J, Damon I K, Jahrling P B, Moss B

机构信息

State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia.

出版信息

Virology. 2002 Jun 5;297(2):172-94. doi: 10.1006/viro.2002.1446.

Abstract

Monkeypox virus (MPV) belongs to the orthopoxvirus genus of the family Poxviridae, is endemic in parts of Africa, and causes a human disease that resembles smallpox. The 196,858-bp MPV genome was analyzed with regard to structural features and open reading frames. Each end of the genome contains an identical but oppositely oriented 6379-bp terminal inverted repetition, which similar to that of other orthopoxviruses, includes a putative telomere resolution sequence and short tandem repeats. Computer-assisted analysis was used to identify 190 open reading frames containing >/=60 amino acid residues. Of these, four were present within the inverted terminal repetition. MPV contained the known essential orthopoxvirus genes but only a subset of the putative immunomodulatory and host range genes. Sequence comparisons confirmed the assignment of MPV as a distinct species of orthopoxvirus that is not a direct ancestor or a direct descendent of variola virus, the causative agent of smallpox.

摘要

猴痘病毒(MPV)属于痘病毒科正痘病毒属,在非洲部分地区呈地方性流行,可引起类似天花的人类疾病。对196,858碱基对的猴痘病毒基因组进行了结构特征和开放阅读框分析。基因组的每一端都包含一个相同但方向相反的6379碱基对末端反向重复序列,与其他正痘病毒的类似,其中包括一个假定的端粒分辨率序列和短串联重复序列。采用计算机辅助分析来鉴定190个包含≥60个氨基酸残基的开放阅读框。其中,四个位于反向末端重复序列内。猴痘病毒包含已知的正痘病毒必需基因,但仅包含假定的免疫调节和宿主范围基因的一个子集。序列比较证实猴痘病毒被归为正痘病毒的一个独特物种,它不是天花病原体天花病毒的直接祖先或直接后代。

相似文献

1
Analysis of the monkeypox virus genome.
Virology. 2002 Jun 5;297(2):172-94. doi: 10.1006/viro.2002.1446.
2
Human monkeypox and smallpox viruses: genomic comparison.
FEBS Lett. 2001 Nov 30;509(1):66-70. doi: 10.1016/s0014-5793(01)03144-1.
3
Specific detection of monkeypox virus by polymerase chain reaction.
J Virol Methods. 1998 Oct;74(2):201-7. doi: 10.1016/s0166-0934(98)00099-8.
4
Independent evolution of monkeypox and variola viruses.
J Virol. 1992 Dec;66(12):7565-7. doi: 10.1128/JVI.66.12.7565-7567.1992.
5
The sequence of camelpox virus shows it is most closely related to variola virus, the cause of smallpox.
J Gen Virol. 2002 Apr;83(Pt 4):855-872. doi: 10.1099/0022-1317-83-4-855.
6
Monkeypox virus and insights into its immunomodulatory proteins.
Immunol Rev. 2008 Oct;225:96-113. doi: 10.1111/j.1600-065X.2008.00691.x.
7
A tale of two clades: monkeypox viruses.
J Gen Virol. 2005 Oct;86(Pt 10):2661-2672. doi: 10.1099/vir.0.81215-0.
8
Alastrim smallpox variola minor virus genome DNA sequences.
Virology. 2000 Jan 20;266(2):361-86. doi: 10.1006/viro.1999.0086.
9
Orthopoxvirus DNA: a comparison of restriction profiles and maps.
Virology. 1985 May;143(1):230-51. doi: 10.1016/0042-6822(85)90111-4.
10
Genome of Alaskapox Virus, A Novel Orthopoxvirus Isolated from Alaska.
Viruses. 2019 Aug 1;11(8):708. doi: 10.3390/v11080708.

引用本文的文献

2
Multivalent mpox protein nanoparticle vaccines confer cross-protection against orthopoxvirus infection.
PLoS Pathog. 2025 Aug 21;21(8):e1013389. doi: 10.1371/journal.ppat.1013389. eCollection 2025 Aug.
3
Clade I or clade II? Targeting essential viral genes to differentiate monkeypox virus clades by multiplex real-time PCR.
Front Public Health. 2025 Aug 1;13:1626030. doi: 10.3389/fpubh.2025.1626030. eCollection 2025.
4
Mpox virus: virology, molecular epidemiology, and global public health challenges.
Front Microbiol. 2025 Jul 17;16:1624110. doi: 10.3389/fmicb.2025.1624110. eCollection 2025.
6
Phylogenetic Analysis of the Mpox Virus in Sub-Saharan Africa (2022-2024).
Biology (Basel). 2025 Jun 26;14(7):773. doi: 10.3390/biology14070773.
8
A robust comprehensive immunoinformatics approach for designing a potential multi-epitope based vaccine against a reiterated monkeypox virus.
Biochem Biophys Rep. 2025 Jun 12;43:102075. doi: 10.1016/j.bbrep.2025.102075. eCollection 2025 Sep.
10
Exploring monkeypox virus antibody levels: insights from human immunological research.
Virol J. 2025 May 31;22(1):175. doi: 10.1186/s12985-025-02748-0.

本文引用的文献

1
HYBRIDS DERIVED FROM THE VIRUSES OF VARIOLA MAJOR AND COWPOX.
J Hyg (Lond). 1964 Jun;62(2):147-58. doi: 10.1017/s0022172400039887.
2
Human monkeypox and smallpox viruses: genomic comparison.
FEBS Lett. 2001 Nov 30;509(1):66-70. doi: 10.1016/s0014-5793(01)03144-1.
3
The A20R protein is a stoichiometric component of the processive form of vaccinia virus DNA polymerase.
J Virol. 2001 Dec;75(24):12298-307. doi: 10.1128/JVI.75.24.12298-12307.2001.
4
The vaccinia virus A41L protein is a soluble 30 kDa glycoprotein that affects virus virulence.
J Gen Virol. 2001 Sep;82(Pt 9):2095-2105. doi: 10.1099/0022-1317-82-9-2095.
6
Outbreak of human monkeypox, Democratic Republic of Congo, 1996 to 1997.
Emerg Infect Dis. 2001 May-Jun;7(3):434-8. doi: 10.3201/eid0703.010311.
7
Immunology 101 at poxvirus U: immune evasion genes.
Semin Immunol. 2001 Feb;13(1):59-66. doi: 10.1006/smim.2000.0296.
8
Regulation of viral intermediate gene expression by the vaccinia virus B1 protein kinase.
J Virol. 2001 May;75(9):4048-55. doi: 10.1128/JVI.75.9.4048-4055.2001.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验