将BMS-284756与环丙沙星、左氧氟沙星、曲伐沙星和莫西沙星的抗肺炎球菌活性进行单步和多步选择研究。
Single- and multistep selection study of the antipneumococcal activity of BMS-284756 compared to ciprofloxacin, levofloxacin, trovafloxacin and moxifloxacin.
作者信息
Clark C L, Nagai K, Davies T A, Bozdogan B, Dewasse B, Jacobs M R, Appelbaum P C
机构信息
Department of Pathology, Hershey Medical Center, PO Box 850, 500 University Drive, Hershey, PA 17033, USA.
出版信息
Clin Microbiol Infect. 2002 Jun;8(6):373-80. doi: 10.1046/j.1469-0691.2002.00405.x.
Single- and Multi-step selection studies were used to test the ability of BMS-284756, ciprofloxacin, levofloxacin, trovafloxacin and moxifloxacin to yield resistant clones from 12 quinolone-susceptible and -resistant Streptococcus pneumoniae strains. Although all quinolones selected, to a greater or lesser degree, for resistant clones with mutations usually in parC or gyrA, BMS-284756 tended to select for resistant clones at a lower rate than other quinolones studied.
采用单步和多步选择研究来测试BMS-284756、环丙沙星、左氧氟沙星、曲伐沙星和莫西沙星从12株喹诺酮敏感和耐药的肺炎链球菌菌株中产生耐药克隆的能力。尽管所有喹诺酮类药物或多或少都会选择出通常在parC或gyrA中发生突变的耐药克隆，但与所研究的其他喹诺酮类药物相比，BMS-284756选择耐药克隆的速率往往较低。
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