Wutzke Sonia E, Conigrave Katherine M, Saunders John B, Hall Wayne D
Faculty of Medicine, University of Sydney, Sydney, Australia.
Addiction. 2002 Jun;97(6):665-75. doi: 10.1046/j.1360-0443.2002.00080.x.
To examine the long-term impact of brief and early interventions for hazardous and harmful alcohol consumption.
A 9-month and 10-year follow-up of subjects recruited into a randomized controlled trial of a range of alcohol-related brief interventions.
General practices, the outpatient or acute care services of a major city hospital, and a privately run health screening programmeme.
The cohort of 554 (non-dependent) hazardous and harmful drinkers recruited into the Australian arm of the Phase II World Health Organization collaborative project on identification and treatment of persons with harmful alcohol consumption.
The effectiveness of three forms of intervention, ranging from 5 to 60 minutes in duration, were compared with a no-treatment control condition.
Included drinking behaviour and biological markers of alcohol use. In addition, at 10 years subjects were asked about symptoms of diagnosable alcohol use disorders and their experience of alcohol-related psychological, social and physical harm. Mortality was also assessed.
Results provide further evidence for the short-term effectiveness of alcohol-related brief interventions. In comparison to controls, subjects offered intervention: (1) report significantly lower consumption; and (2) less unsafe drinking at 9-month follow-up. The intensity of intervention was not related to the amount of change in drinking behaviour. Analysis at 10 years failed to find any differences in outcomes between intervention and control groups in median consumption, mean reduction in consumption from baseline to follow-up, mortality and ICD-10 diagnoses of alcohol dependence or harmful alcohol use.
This study failed to find evidence that brief advice and counselling without regular follow-up and reinforcement can sustain significant long-term reductions in drinking behaviour at 10-year follow-up.
探讨针对危险及有害饮酒行为的简短早期干预措施的长期影响。
对纳入一系列与酒精相关简短干预随机对照试验的受试者进行为期9个月和10年的随访。
全科医疗、某大城市医院的门诊或急症护理服务部门以及一个私立健康筛查项目。
554名（非依赖型）危险及有害饮酒者组成的队列，他们被纳入世界卫生组织关于识别和治疗有害饮酒者的第二阶段协作项目的澳大利亚分支。
将三种时长从5至60分钟不等的干预形式的效果与无治疗对照条件进行比较。
包括饮酒行为及酒精使用的生物学标志物。此外，在10年时询问受试者可诊断的酒精使用障碍症状以及他们在酒精相关心理、社会和身体伤害方面的经历。还评估了死亡率。
结果为与酒精相关简短干预措施的短期有效性提供了进一步证据。与对照组相比，接受干预的受试者：（1）报告饮酒量显著更低；（2）在9个月随访时不安全饮酒情况更少。干预强度与饮酒行为的变化量无关。10年时的分析未发现干预组和对照组在中位饮酒量、从基线到随访的平均饮酒量减少、死亡率以及国际疾病分类第十版（ICD - 10）诊断的酒精依赖或有害酒精使用方面存在任何差异。
本研究未找到证据表明，在无定期随访和强化的情况下，简短建议和咨询能在10年随访时持续显著减少饮酒行为。
