Kawachi Takashi, Ishii Kazunari, Sakamoto Setsu, Matsui Mieko, Mori Tetsuya, Sasaki Masahiro
Division of Imaging Research, Hyogo Institute for Aging Brain and Cognitive Disorders, 520 Saisho-Ko, Himeji, Hyogo 670-0981, Japan.
J Neurol Sci. 2002 Jul 15;199(1-2):79-83. doi: 10.1016/s0022-510x(02)00112-0.
Some studies have examined gender differences in brain function based on cerebral blood flow and cerebral metabolism by using positron emission tomography (PET). However, the findings of these studies are controversial and most of them were analyzed by the regions of interest (ROIs) method. Here, we evaluated gender differences of cerebral glucose metabolism under the resting state in a voxel-based analysis.
We studied 44 healthy volunteers (22 females, 63.0+/-6.3 years, and 22 males, 63.1+/-8.4 years). Cerebral glucose metabolic images were obtained with (18)F-fluorodeoxyglucose (FDG) and PET. All individual data were transformed to standard brain space and the male and female groups were compared using statistical parametric mapping (SPM).
The males had significantly higher glucose metabolism in the right insula, middle temporal gyrus, and medial frontal lobe than the females. Glucose metabolism in the hypothalamus was significantly higher in females than in males. There was a significant correlation between aging and glucose metabolism in the left thalamus in males and in the left caudate nucleus and hypothalamus in females. In males, but not females, there was a significant asymmetry between the bilateral hemispheres.
We found that there were obvious gender differences in regional cerebral glucose metabolism and this is the first report of higher glucose metabolism in the hypothalamus in females than in males.
一些研究通过正电子发射断层扫描（PET）基于脑血流量和脑代谢来研究脑功能的性别差异。然而，这些研究的结果存在争议，并且大多数是通过感兴趣区域（ROI）方法进行分析的。在此，我们在基于体素的分析中评估静息状态下脑葡萄糖代谢的性别差异。
我们研究了44名健康志愿者（22名女性，年龄63.0±6.3岁，22名男性，年龄63.1±8.4岁）。使用（18）F-氟脱氧葡萄糖（FDG）和PET获得脑葡萄糖代谢图像。所有个体数据都转换到标准脑空间，并使用统计参数映射（SPM）比较男性和女性组。
男性在右侧岛叶、颞中回和内侧额叶的葡萄糖代谢显著高于女性。女性下丘脑的葡萄糖代谢显著高于男性。男性左侧丘脑以及女性左侧尾状核和下丘脑的衰老与葡萄糖代谢之间存在显著相关性。在男性中，而非女性中，双侧半球之间存在显著不对称性。
我们发现局部脑葡萄糖代谢存在明显的性别差异，并且这是首次报道女性下丘脑的葡萄糖代谢高于男性。
