牛乙酰辅酶A羧化酶α编码基因的启动子II在不同细胞中广泛表达且活性很强。
Promoter II of the bovine acetyl-coenzyme A carboxylase-alpha-encoding gene is widely expressed and strongly active in different cells.
作者信息
Mao Jianqiang, Seyfert Hans-Martin
机构信息
Research Institute for the Biology of Farm Animals, Wilhelm-Stahl-Allee 2, D-18196 Dummerstorf, Germany.
出版信息
Biochim Biophys Acta. 2002 Jul 19;1576(3):324-9. doi: 10.1016/s0167-4781(02)00369-x.
Three promoters express the bovine gene encoding the enzyme acetyl-CoA carboxylase-alpha (ACC alpha) known to be rate-limiting for fatty acid synthesis. Our sequence of promoter II shows that PII is evolutionary conserved, unlike PI or PIII. In vivo expression of PII reveals little tissue-specific restrictions. The proximal 133 bp of this promoter are sufficient for a strong basal expression in different cell lines.
三种启动子表达编码乙酰辅酶A羧化酶α（ACCα）的牛基因，已知该酶对脂肪酸合成具有限速作用。我们的启动子II序列显示，与启动子I或启动子III不同，启动子II在进化上是保守的。启动子II的体内表达几乎没有组织特异性限制。该启动子近端的133个碱基对足以在不同细胞系中实现强大的基础表达。
Zotero 插件