肉毒杆菌毒素可改善眼睑痉挛相关的眼睑开合失用症中的眼睑张开延迟。

Botulinum toxin improves lid opening delays in blepharospasm-associated apraxia of lid opening.

作者信息

Forget Robert, Tozlovanu Viorika, Iancu Andreea, Boghen Dan

机构信息

Centre de recherche interdisciplinaire en réadaptation du Montréal Métropolitain, Institut de Réadaptation de Montréal, Qué H3S 2J4, Canada.

出版信息

Neurology. 2002 Jun 25;58(12):1843-6. doi: 10.1212/wnl.58.12.1843.

DOI:10.1212/wnl.58.12.1843

PMID:12084888

Abstract

Lid movement and EMG of the orbicularis oculi (OOc) were analyzed in 10 patients with apraxia of lid opening associated with blepharospasm before and after botulinum toxin treatment. The latencies to onset and to complete the eye opening and the time during which eye opening was sustained were studied in relation to OOc activity and compared with control values obtained in 12 healthy subjects. Following treatment there was an improvement of all lid opening measurements, a decrease of the abnormally prolonged OOc activity, and a reduction of the functional disability.

摘要

对10例伴有眼睑痉挛的睁眼失用症患者在肉毒杆菌毒素治疗前后进行了眼睑运动和眼轮匝肌肌电图（OOc）分析。研究了与眼轮匝肌活动相关的睁眼起始潜伏期、睁眼完成潜伏期以及睁眼持续时间，并与12名健康受试者的对照值进行比较。治疗后，所有睁眼测量指标均有所改善，异常延长的眼轮匝肌活动减少，功能障碍减轻。