Reinhard G, Märten A, Kiske S M, Feil F, Bieber T, Schmidt-Wolf I G H
Klinik und Poliklinik für Dermatologie der Rheinischen Friedrich-Wilhelms-Universität Bonn, Germany.
Br J Cancer. 2002 May 20;86(10):1529-33. doi: 10.1038/sj.bjc.6600316.
Dendritic cells play a major role in the generation of immunity against tumour cells. They can be grown under various culture conditions, which influence the phenotypical and functional properties of dendritic cells and thereby the consecutive immune response mainly executed by T cells. Here we discuss various conditions, which are important during generation and administration of dendritic cells to elicit a tumouricidal T cell-based immune response.
树突状细胞在针对肿瘤细胞的免疫反应产生过程中发挥着主要作用。它们可以在多种培养条件下生长，这些条件会影响树突状细胞的表型和功能特性，进而影响主要由T细胞执行的后续免疫反应。在此，我们讨论在树突状细胞的生成和给药过程中各种重要条件，以引发基于T细胞杀瘤作用的免疫反应。
