Ding Zhaohua, Zhu Hui, Friedman Morton H
Department of Diagnostic Radiology, Yale University, New Haven, CT, USA.
Ann Biomed Eng. 2002 Apr;30(4):419-29. doi: 10.1114/1.1467925.
There is considerable evidence that the localization and evolution of vascular disease are mediated, at least in part, by mechanical factors. The mechanical environment of the coronary arteries, which are tethered to the beating heart, is influenced by cardiac motion; the motion of the vessels must be described quantitatively to characterize fully the mechanical forces acting on and in the vessel wall. Several techniques that have been used to characterize coronary artery dynamics from biplane cineangiograms are described and illustrated. There is considerable variability in dynamic geometric parameters from site to site along a vessel, between the right and left anterior descending arteries, and among individuals, consistent with the hypotheses that variations in stresses mediated by geometry and dynamics affect the localization of atherosclerosis and individual risk of coronary heart disease. The few frankly atherosclerotic vessels that have been examined exhibit high torsions in the neighborhood of lesions, an observation which may have etiologic or diagnostic implications.
有大量证据表明，血管疾病的定位和演变至少部分是由机械因素介导的。冠状动脉与跳动的心脏相连，其机械环境受心脏运动影响；必须对血管的运动进行定量描述，才能全面表征作用于血管壁内外的机械力。本文描述并展示了几种用于从双平面电影血管造影中表征冠状动脉动力学的技术。沿血管不同部位、左右前降支动脉之间以及个体之间，动态几何参数存在相当大的变异性，这与以下假设一致，即由几何形状和动力学介导的应力变化会影响动脉粥样硬化的定位和个体患冠心病的风险。少数已检查的明显动脉粥样硬化血管在病变附近表现出高扭转，这一观察结果可能具有病因学或诊断学意义。
