大G蛋白与小G蛋白：G蛋白与肌动蛋白细胞骨架重组
Big G, little G: G proteins and actin cytoskeletal reorganization.
作者信息
Luttrell Louis M
机构信息
The Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
出版信息
Mol Cell. 2002 Jun;9(6):1152-4. doi: 10.1016/s1097-2765(02)00551-8.
Abstract
It has been known for some time that stimulation of heterotrimeric G protein-coupled receptors can cause cytoskeletal reorganization. A recent report in Developmental Cell demonstrates that the activation of a tyrosine kinase, C-terminal Src kinase, by heterotrimeric G protein subunits provides the trigger for Rho-dependent actin stress fiber formation.
摘要
一段时间以来，人们已经知道异源三聚体G蛋白偶联受体的刺激可导致细胞骨架重组。《发育细胞》最近的一篇报道表明，异源三聚体G蛋白亚基对酪氨酸激酶C末端Src激酶的激活为Rho依赖性肌动蛋白应力纤维的形成提供了触发因素。
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