RUNX：癌症基因三部曲。

RUNX: a trilogy of cancer genes.

作者信息

Lund Anders H, van Lohuizen Maarten

机构信息

Division of Molecular Genetics, The Netherlands Cancer Institute, Antoni van Leeuwenhoek ziekenhuis, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands

出版信息

Cancer Cell. 2002 Apr;1(3):213-5. doi: 10.1016/s1535-6108(02)00049-1.

DOI:10.1016/s1535-6108(02)00049-1

PMID:12086855

Abstract

The RUNX family of transcription factors plays pivotal roles during normal development and in neoplasias. Recent data involve RUNX3 as an important tumor suppressor in gastric cancers and pose interesting questions about how perturbed levels and interspecific competition among RUNX family members may contribute to tumorigenesis.

摘要

转录因子RUNX家族在正常发育和肿瘤形成过程中发挥着关键作用。最近的数据表明RUNX3是胃癌中的一种重要肿瘤抑制因子，并引发了关于RUNX家族成员水平紊乱和种间竞争如何促进肿瘤发生的有趣问题。