Ghoneim M M, Mewaldt S P
Psychopharmacologia. 1975 Nov 21;44(3):257-62. doi: 10.1007/BF00428903.
The effects of intramuscular injections of diazepam (0.3 mg/kg) and scopolamine (8 mug/kg) on memory processes and subjective moods were studied in 36 volunteers. Subjects (Ss) were tested in groups of four in a double blind procedure with treatments distributed according to a Latin square design. Lists of words were presented to Ss who were then tested with an immediate free recall test prior to drug administration. Following injection delayed free recall and recognition tests were given. Subsequently two sets of lists were presented separately and tested in the same fashion. Two of the lists in the last set were composed of words falling into distinct categories. Memory was additionally analyzed by testing immediate recall of digit sequences and employing a visual recognition test. Subjective moods were evaluated with a rating questionnaire. Both diazepam and scopolamine impaired memory functions although the action of the latter drug was more pronounced and prolonged. The deficit appeared to be in the storage process leaving retrieval processes unaffected. Scopolamine in addition interfered with organizational processes. Subjectively, scopolamine also produced a larger sedative effect than diazepam.
在36名志愿者中研究了肌肉注射地西泮（0.3毫克/千克）和东莨菪碱（8微克/千克）对记忆过程和主观情绪的影响。受试者按四人一组在双盲程序中进行测试，治疗根据拉丁方设计分配。向受试者呈现单词列表，然后在给药前对他们进行即时自由回忆测试。注射后进行延迟自由回忆和识别测试。随后分别呈现两组列表并以相同方式进行测试。最后一组中的两个列表由属于不同类别的单词组成。通过测试数字序列的即时回忆并采用视觉识别测试对记忆进行额外分析。用评分问卷评估主观情绪。地西泮和东莨菪碱均损害记忆功能，尽管后一种药物的作用更明显且持续时间更长。缺陷似乎在于存储过程，而检索过程未受影响。此外，东莨菪碱干扰了组织过程。在主观上，东莨菪碱也比地西泮产生更大的镇静作用。
