Bertrand Nicolas, Castro Diogo S, Guillemot François
Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ Université Louis Pasteur, B.P. 163, 67404 Illkirch cedex, C.U. de Strasbourg, France.
Nat Rev Neurosci. 2002 Jul;3(7):517-30. doi: 10.1038/nrn874.
Certain morphological, physiological and molecular characteristics are shared by all neurons. However, despite these similarities, neurons constitute the most diverse cell population of any organism. Recently, considerable attention has been focused on identifying the molecular mechanisms that underlie this cellular diversity. Parallel studies in Drosophila and vertebrates have revealed that proneural genes are key regulators of neurogenesis, coordinating the acquisition of a generic neuronal fate and of specific subtype identities that are appropriate for the location and time of neuronal generation. These studies reveal that, in spite of differences between invertebrate and vertebrate neural lineages, Drosophila and vertebrate proneural genes have remarkably similar roles.
所有神经元都具有某些形态、生理和分子特征。然而，尽管存在这些相似性，神经元却是所有生物体中最多样化的细胞群体。最近，人们相当关注确定这种细胞多样性背后的分子机制。在果蝇和脊椎动物中的平行研究表明，原神经基因是神经发生的关键调节因子，协调获得一般神经元命运以及适合神经元生成位置和时间的特定亚型身份。这些研究表明，尽管无脊椎动物和脊椎动物神经谱系存在差异，但果蝇和脊椎动物的原神经基因具有非常相似的作用。
