从红厚壳属植物中分离得到的卡罗齐氧杂蒽酮对耐万古霉素肠球菌（VRE）的抗菌活性及其与抗生素的协同作用。
Antibacterial activity of calozeyloxanthone isolated from Calophyllum species against vancomycin-resistant Enterococci (VRE) and synergism with antibiotics.
作者信息
Sakagami Y, Kajimura K, Wijesinghe W M N M, Dharmaratne H R W
出版信息
Planta Med. 2002 Jun;68(6):541-3. doi: 10.1055/s-2002-32558.
Calozeyloxanthone ( 1) was re-isolated from the root bark of Calophyllum moonii, an endemic species of Sri Lanka, and found to be active against vancomycin-resistant Enterococci (VRE) and vancomycin-sensitive Enterococci (VSE) with MIC values of 6.25 microg/ml and 12.5 microg/ml, respectively. Further, a marked synergism between 1 and vancomycin hydrochloride (VCM) against VRE was also observed. These findings suggest that 1 in combination with VCM against VRE may be useful in controlling VRE infections.
从斯里兰卡特有物种月桂叶红厚壳的根皮中重新分离出了卡洛泽黄烷酮（1），发现其对耐万古霉素肠球菌（VRE）和万古霉素敏感肠球菌（VSE）具有活性，其最低抑菌浓度（MIC）值分别为6.25微克/毫升和12.5微克/毫升。此外，还观察到1与盐酸万古霉素（VCM）对VRE有明显的协同作用。这些发现表明，1与VCM联合用于对抗VRE可能有助于控制VRE感染。
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