Porstmann Agnes Ute, Marcus Ulrich, Pleyer Uwe
Universitätsaugenklinik Charité, Fakultät der Humboldt-Universität Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin.
Klin Monbl Augenheilkd. 2002 May;219(5):349-52. doi: 10.1055/s-2002-32632.
Throughout the developed world the reported incidence of sexually transmitted diseases is rising with previously unreported cases at rates of 40 - 70 %. According to German sources, recent epidemiological data show a considerable increase of syphilis especially among homosexual men in larger cities.
We report on 4 patients (age 38 - 54) who were referred to our outpatient department because of vision loss of unknown origin. All were subsequently tested positive for syphilis. None of the patients (3 men, 1 woman) belonged to a risk group, only one described systemic symptoms (urethritis and arthritis). The ocular manifestations of syphilis were broad: granulomatous and non-granulomatous anterior uveitis, papillitis, and chorioretinitis. Two patients also tested positive for HIV. After systemic antibiotic therapy, the ocular diseases stabilized.
Diagnosis and therapy of syphilis is cost-effective. The rise of syphilis especially in urban areas necessitates a high level of suspicion dealing with patients with intraocular inflammation of unknown origin. Lues serology should be incorporated into routine lab diagnostics to aid in the detection of such cases.
在整个发达国家,性传播疾病的报告发病率正在上升,以前未报告的病例以40% - 70%的速度增加。根据德国的资料来源,最近的流行病学数据显示梅毒发病率大幅上升,尤其是在大城市的男同性恋者中。
我们报告了4例患者(年龄38 - 54岁),他们因不明原因的视力丧失被转诊至我们的门诊。所有患者随后梅毒检测均呈阳性。这些患者(3名男性,1名女性)均不属于高危人群,只有1名患者描述有全身症状(尿道炎和关节炎)。梅毒的眼部表现多种多样:肉芽肿性和非肉芽肿性前葡萄膜炎、视乳头炎和脉络膜视网膜炎。2名患者HIV检测也呈阳性。经过全身抗生素治疗后,眼部疾病病情稳定。
梅毒的诊断和治疗具有成本效益。梅毒发病率的上升,尤其是在城市地区,对于不明原因眼内炎症患者需要高度怀疑。梅毒血清学应纳入常规实验室诊断,以帮助检测此类病例。