抗氧化脂质体的治疗用途。
Therapeutic uses of antioxidant liposomes.
作者信息
Stone William L, Mukherjee Shyamali, Smith Milton, Das Salil K
机构信息
Department of Pediatrics, East Tennessee State University, Johnson City, TN, USA.
出版信息
Methods Mol Biol. 2002;199:145-61. doi: 10.1385/1-59259-175-2:145.
This chapter focuses on the use of antioxidant liposomes in the general area of free radical biology and medicine. The term is relatively new and refers to liposomes containing lipid-soluble chemical antioxidants, water-soluble chemical antioxidants, enzymatic antioxidants, or combinations of these various antioxidants. The role of antioxidants in health and disease has been extensively discussed, and many excellent reviews and books are available (–3). Antioxidant liposomes hold great promise in the treatment of many diseases in which oxidative stress plays a prominent role. Oxidative stress is a physiological condition in which the production of damaging free radicals exceeds the in vivo capacity of antioxidant protection mechanisms to prevent pathophysiology. Free radicals are molecules with unpaired electrons, often highly reactive and damaging to biological systems. The biological membranes of subcellular organelles are a major site of free radical damage but proteins and DNA are also significant targets. Moreover, free radicals can alter cellular signal transduction pathways and stimulate the synthesis of inflammatory cytokines. Oxygen radicals and other reactive oxygen species (ROS) arise from the single electron reductions of oxygen.
本章重点关注抗氧化脂质体在自由基生物学和医学这一广泛领域中的应用。这个术语相对较新，指的是含有脂溶性化学抗氧化剂、水溶性化学抗氧化剂、酶促抗氧化剂或这些不同抗氧化剂组合的脂质体。抗氧化剂在健康和疾病中的作用已得到广泛讨论，有许多优秀的综述和书籍可供参考（-3）。抗氧化脂质体在治疗许多氧化应激起重要作用的疾病方面具有巨大潜力。氧化应激是一种生理状态，其中破坏性自由基的产生超过了体内抗氧化保护机制预防病理生理的能力。自由基是具有未配对电子的分子，通常具有高反应性且会对生物系统造成损害。亚细胞器的生物膜是自由基损伤的主要部位，但蛋白质和DNA也是重要靶点。此外，自由基可改变细胞信号转导途径并刺激炎性细胞因子的合成。氧自由基和其他活性氧（ROS）源自氧的单电子还原。
Zotero 插件