Ednie Lois M, Jacobs Michael R, Appelbaum Peter C
Department of Pathology, Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA.
J Antimicrob Chemother. 2002 Jul;50(1):101-5. doi: 10.1093/jac/dkf088.
The anti-anaerobic activity of AZD2563, a new oxazolidinone, was compared with that of eight other agents against 201 Gram-positive and 99 Gram-negative anaerobes. MIC(50) and MIC(90) values (mg/L) for the 201 Gram-positive organisms were as follows: AZD2563, 1.0/4.0; linezolid, 1.0/4.0; quinupristin/dalfopristin, 0.5/1.0; amoxicillin, 0.25/1.0; clindamycin, 0.25/8.0; metronidazole, 0.5/>16.0; vancomycin, 0.5/2.0; teicoplanin, 0.125/0.25; and meropenem, 0.06/1.0. AZD2563, linezolid, vancomycin, teicoplanin and quinupristin/dalfopristin were mainly active against Gram-positive anaerobes, with no useful activity against Gram-negative anaerobes.
将新型恶唑烷酮类药物AZD2563的抗厌氧活性与其他八种药物针对201株革兰氏阳性厌氧菌和99株革兰氏阴性厌氧菌的抗厌氧活性进行了比较。201株革兰氏阳性菌的MIC(50)和MIC(90)值（mg/L）如下：AZD2563，1.0/4.0；利奈唑胺，1.0/4.0；奎奴普丁/达福普汀，0.5/1.0；阿莫西林，0.25/1.0；克林霉素，0.25/8.0；甲硝唑，0.5/>16.0；万古霉素，0.5/2.0；替考拉宁，0.125/0.25；美罗培南，0.06/1.0。AZD2563、利奈唑胺、万古霉素、替考拉宁和奎奴普丁/达福普汀主要对革兰氏阳性厌氧菌有活性，对革兰氏阴性厌氧菌无有效活性。
