TBX2在与BRCA1和BRCA2相关的乳腺肿瘤中优先扩增。

TBX2 is preferentially amplified in BRCA1- and BRCA2-related breast tumors.

作者信息

Sinclair Colleen S, Adem Camilo, Naderi Ali, Soderberg Cheryl L, Johnson Michele, Wu Kangjian, Wadum Linda, Couch Vicki L, Sellers Thomas A, Schaid Daniel, Slezak Jeffrey, Fredericksen Zach, Ingle James N, Hartmann Lynn, Jenkins Robert B, Couch Fergus J

机构信息

Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.

出版信息

Cancer Res. 2002 Jul 1;62(13):3587-91.

PMID:12097257

Abstract

The chromosome 17q23 region is frequently amplified in breast tumors. Gain of the region is present in 50% of BRCA1-associated breast tumors and 87% of BRCA2-associated breast tumors. The amplification frequency of the RPS6KB1 and TBX2 oncogenes from this amplicon was compared in 27 BRCA1 and BRCA2 mutant breast tumors, 15 breast tumors from high-risk patients with no BRCA1 or BRCA2 mutations, and 62 matched sporadic breast tumor controls. TBX2 was determined to be preferentially amplified and overexpressed in BRCA1 and BRCA2 mutant tumors, whereas RPS6KB1 was not, suggesting a role for TBX2 amplification in the development of BRCA1- and BRCA2-associated breast tumors.

摘要

17号染色体q23区域在乳腺肿瘤中经常发生扩增。该区域的增益存在于50%的BRCA1相关乳腺肿瘤和87%的BRCA2相关乳腺肿瘤中。在27例BRCA1和BRCA2突变型乳腺肿瘤、15例来自无BRCA1或BRCA2突变的高危患者的乳腺肿瘤以及62例匹配的散发性乳腺肿瘤对照中，比较了来自该扩增子的RPS6KB1和TBX2癌基因的扩增频率。结果确定TBX2在BRCA1和BRCA2突变肿瘤中优先扩增并过表达，而RPS6KB1则不然，这表明TBX2扩增在BRCA1和BRCA2相关乳腺肿瘤的发生发展中起作用。