Hasegawa Toshimichi, Sasaki Takashi, Kimura Takuya, Okada Akira, Nakatsuchi Yoshiaki, Sugiura Takashi, Kato Hiromi, Nakajima Yoshikazu
Department of Pediatric Surgery, Osaka University, Medical School, Osaka, Japan.
Pediatr Transplant. 2002 Jun;6(3):244-8. doi: 10.1034/j.1399-3046.2002.01081.x.
A 1-yr-old girl underwent a living-related liver transplant, with reconstruction of hepatic artery of 2 mm in diameter under microscopy. She developed intestinal perforation requiring closure on day 4 post-transplant and suffered from hepatic artery stenosis (HAS) on post-transplant day 9. Conservative therapies, such as intravenous or transluminal administration of anti-coagulants, vasodilators or fluids, were unsuccessful and caused remarkable general edema and multiple arrhythmias as a result of increased preload. On day 15 post-transplant, because flow velocity was remarkably reduced (as shown by Doppler ultrasound) the patient underwent percutaneous transluminal angioplasty (PTA) using a kit for coronary angioplasty. The balloon catheter was inflated [first: 1.5 mm diameter, 4 atmospheric pressure (a.p.) for 30 seconds (s); second: 2.0 mm diameter, 4 a.p. for 30 s; third: 2.5 mm diameter, 10 a.p. for 30 s]. The stenosis was successfully dilated without any complication. The patient has been doing well with normal liver functions for 4 months after PTA. From this experience, PTA can be performed for HAS after liver transplantation, even in an infantile case, with a careful technique and a special device.
一名1岁女童接受了亲属活体肝移植,术中在显微镜下对直径2毫米的肝动脉进行了重建。术后第4天,她出现肠道穿孔,需要进行缝合;术后第9天,又出现了肝动脉狭窄(HAS)。静脉注射或经腔给予抗凝剂、血管扩张剂或补液等保守治疗均未成功,且由于前负荷增加导致了明显的全身性水肿和多种心律失常。术后第15天,因多普勒超声显示血流速度显著降低,患者使用冠状动脉成形术套件接受了经皮腔内血管成形术(PTA)。球囊导管进行了三次扩张[第一次:直径1.5毫米,4个大气压(a.p.),持续30秒(s);第二次:直径2.0毫米,4 a.p.,持续30 s;第三次:直径2.5毫米,10 a.p.,持续30 s]。狭窄成功扩张,未出现任何并发症。PTA术后4个月,患者肝功能正常,情况良好。根据这一经验,即使是婴幼儿病例,肝移植术后发生HAS时,采用谨慎的技术和特殊装置也可进行PTA。