Suppr超能文献

肾细胞癌的临床和病理肿瘤大小;差异、相关性及影响因素分析

Clinical and pathologic tumor size in renal cell carcinoma; difference, correlation, and analysis of the influencing factors.

作者信息

Yaycioglu Ozgur, Rutman Matthew P, Balasubramaniam Mamtha, Peters Kenneth M, Gonzalez Jose A

机构信息

Department of Urology, William Beaumont Hospital, Royal Oak, Michigan, USA.

出版信息

Urology. 2002 Jul;60(1):33-8. doi: 10.1016/s0090-4295(02)01668-0.

Abstract

OBJECTIVES

To investigate the relation between the clinical and pathologic size and to identify the factors that affect this relationship. The clinical size of the tumor is essential for choosing the appropriate treatment in renal cell carcinoma. The pathologic size, on the other hand, is an important prognostic indicator.

METHODS

We reviewed the charts of 291 open nephrectomy patients treated for nonmetastatic renal cell carcinoma. Clinical size was defined as the largest diameter on contrast-enhanced computed tomography. Pathologic size was defined as the largest diameter on pathologic examination. The clinical and pathologic sizes were compared, and their correlation was analyzed. The effect of various clinical and pathologic factors on the percentage of the size difference (%Delta(size)) was analyzed.

RESULTS

The mean clinical and pathologic size was 5.4 +/- 3.2 and 5.3 +/- 3.3 cm, respectively. The difference was not significant (P = 0.1679). The clinical and pathologic size also correlated highly (r = 0.9540; P <0.0001). The estimated blood loss, local tumor extension, and cell type had significant influence on the %Delta(size) (P = 0.0018, 0.0415, and 0.0079, respectively). Additionally, in approximately one half of the patients with the greatest size difference, features such as cystic masses, hemorrhage, pyelonephritis, localization near or invasion of the collecting system, cysts or dilated calices adjacent to the tumor, and multiple cysts within the kidney were present, which were identified as factors that might have influenced the accuracy of the clinical size.

CONCLUSIONS

The overall accuracy of the clinical size and its correlation with the pathologic size was acceptable. However, the presence of the above-mentioned factors should be taken into consideration during the interpretation of clinical tumor size.

摘要

目的

研究临床大小与病理大小之间的关系,并确定影响这种关系的因素。肿瘤的临床大小对于选择肾细胞癌的合适治疗方法至关重要。另一方面,病理大小是一个重要的预后指标。

方法

我们回顾了291例接受非转移性肾细胞癌开放肾切除术患者的病历。临床大小定义为对比增强计算机断层扫描上的最大直径。病理大小定义为病理检查时的最大直径。比较临床大小和病理大小,并分析它们的相关性。分析各种临床和病理因素对大小差异百分比(%Delta(size))的影响。

结果

临床大小和病理大小的平均值分别为5.4±3.2 cm和5.3±3.3 cm。差异不显著(P = 0.1679)。临床大小和病理大小也高度相关(r = 0.9540;P <0.0001)。估计失血量、局部肿瘤扩展和细胞类型对%Delta(size)有显著影响(分别为P = 0.0018、0.0415和0.0079)。此外,在大约一半大小差异最大的患者中,存在诸如囊性肿块、出血、肾盂肾炎、靠近或侵犯集合系统、肿瘤旁囊肿或扩张的肾盏以及肾内多个囊肿等特征,这些被确定为可能影响临床大小准确性的因素。

结论

临床大小的总体准确性及其与病理大小的相关性是可以接受的。然而,在解释临床肿瘤大小时应考虑上述因素的存在。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验