天蓝色链霉菌BldB蛋白的结构与遗传分析
Structural and genetic analysis of the BldB protein of Streptomyces coelicolor.
作者信息
Eccleston Marcus, Ali Reem Ahmed, Seyler Richard, Westpheling Janet, Nodwell Justin
机构信息
Antimicrobial Research Centre and Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada L8N 3Z5.
出版信息
J Bacteriol. 2002 Aug;184(15):4270-6. doi: 10.1128/JB.184.15.4270-4276.2002.
Abstract
We have demonstrated that the bldB gene of Streptomyces coelicolor is required for the formation of aerial hyphae and the synthesis of antibiotics. We also found that BldB forms a higher-order complex (most likely a dimer) and that amino acid residues 20 to 78 are important for this interaction. This region is conserved in the BldB family, suggesting that dimer formation may be a common feature of these proteins.
摘要
我们已经证明，天蓝色链霉菌的bldB基因是气生菌丝形成和抗生素合成所必需的。我们还发现，BldB形成一种高阶复合物（很可能是二聚体），并且20至78位氨基酸残基对于这种相互作用很重要。该区域在BldB家族中是保守的，这表明二聚体形成可能是这些蛋白质的一个共同特征。
相似文献
1
Structural and genetic analysis of the BldB protein of Streptomyces coelicolor.
J Bacteriol. 2002 Aug;184(15):4270-6. doi: 10.1128/JB.184.15.4270-4276.2002.
2
The bldB gene encodes a small protein required for morphogenesis, antibiotic production, and catabolite control in Streptomyces coelicolor.
J Bacteriol. 1998 Mar;180(6):1556-62. doi: 10.1128/JB.180.6.1556-1562.1998.
3
A novel Streptomyces gene, samR, with different effects on differentiation of Streptomyces ansochromogenes and Streptomyces coelicolor.
Arch Microbiol. 2002 Mar;177(3):274-8. doi: 10.1007/s00203-001-0382-2. Epub 2002 Jan 8.
4
Critical residues and novel effects of overexpression of the Streptomyces coelicolor developmental protein BldB: evidence for a critical interacting partner.
J Bacteriol. 2006 Dec;188(23):8189-95. doi: 10.1128/JB.01119-06. Epub 2006 Sep 8.
5
The bldD gene of Streptomyces coelicolor A3(2): a regulatory gene involved in morphogenesis and antibiotic production.
J Bacteriol. 1998 Mar;180(6):1549-55. doi: 10.1128/JB.180.6.1549-1555.1998.
6
Growth and viability of Streptomyces coelicolor mutant for the cell division gene ftsZ.
Mol Microbiol. 1994 Oct;14(2):243-54. doi: 10.1111/j.1365-2958.1994.tb01285.x.
7
Study of the bldG locus suggests that an anti-anti-sigma factor and an anti-sigma factor may be involved in Streptomyces coelicolor antibiotic production and sporulation.
Microbiology (Reading). 2000 Sep;146 ( Pt 9):2161-2173. doi: 10.1099/00221287-146-9-2161.
8
The rpoZ gene, encoding the RNA polymerase omega subunit, is required for antibiotic production and morphological differentiation in Streptomyces kasugaensis.
J Bacteriol. 2002 Dec;184(23):6417-23. doi: 10.1128/JB.184.23.6417-6423.2002.
9
Genomewide insertional mutagenesis in Streptomyces coelicolor reveals additional genes involved in morphological differentiation.
Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9642-7. doi: 10.1073/pnas.170059797.
10
The Streptomyces coelicolor A3(2) bldB region contains at least two genes involved in morphological development.
J Gen Microbiol. 1990 Aug;136(8):1543-50. doi: 10.1099/00221287-136-8-1543.
引用本文的文献
1
Global Effects of the Developmental Regulator BldB in Streptomyces venezuelae.
J Bacteriol. 2023 Jun 27;205(6):e0013523. doi: 10.1128/jb.00135-23. Epub 2023 May 30.
2
Comparative Proteomic Analysis of Transcriptional and Regulatory Proteins Abundances in and Suggests a Link between Various Stresses and Antibiotic Production.
Int J Mol Sci. 2022 Nov 26;23(23):14792. doi: 10.3390/ijms232314792.
3
High-Throughput Transcriptional Characterization of Regulatory Sequences from Bacterial Biosynthetic Gene Clusters.
ACS Synth Biol. 2021 Aug 20;10(8):1859-1873. doi: 10.1021/acssynbio.0c00639. Epub 2021 Jul 21.
4
Elucidating the Regulatory Elements for Transcription Termination and Posttranscriptional Processing in the Streptomyces clavuligerus Genome.
mSystems. 2021 May 4;6(3):e01013-20. doi: 10.1128/mSystems.01013-20.
5
Carbon catabolite regulation of secondary metabolite formation, an old but not well-established regulatory system.
Microb Biotechnol. 2022 Apr;15(4):1058-1072. doi: 10.1111/1751-7915.13791. Epub 2021 Mar 6.
6
Proteomics analysis of global regulatory cascades involved in clavulanic acid production and morphological development in Streptomyces clavuligerus.
J Ind Microbiol Biotechnol. 2016 Apr;43(4):537-55. doi: 10.1007/s10295-016-1733-y. Epub 2016 Jan 20.
7
Intraspecies comparison of Streptomyces pratensis genomes reveals high levels of recombination and gene conservation between strains of disparate geographic origin.
BMC Genomics. 2014 Nov 15;15(1):970. doi: 10.1186/1471-2164-15-970.
8
Signals and regulators that govern Streptomyces development.
FEMS Microbiol Rev. 2012 Jan;36(1):206-31. doi: 10.1111/j.1574-6976.2011.00317.x. Epub 2011 Dec 2.
9
Metabolic and evolutionary insights into the closely-related species Streptomyces coelicolor and Streptomyces lividans deduced from high-resolution comparative genomic hybridization.
BMC Genomics. 2010 Dec 1;11:682. doi: 10.1186/1471-2164-11-682.
10
Small non-coding RNAs in Streptomyces coelicolor.
Nucleic Acids Res. 2008 Dec;36(22):7240-51. doi: 10.1093/nar/gkn898. Epub 2008 Nov 12.
本文引用的文献
1
Streptomycetes: a new model to study cell death.
Int Microbiol. 2000 Sep;3(3):153-8.
2
Genomewide insertional mutagenesis in Streptomyces coelicolor reveals additional genes involved in morphological differentiation.
Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9642-7. doi: 10.1073/pnas.170059797.
3
The BldD protein from Streptomyces coelicolor is a DNA-binding protein.
J Bacteriol. 1999 Nov;181(21):6832-5. doi: 10.1128/JB.181.21.6832-6835.1999.
4
New sporulation loci in Streptomyces coelicolor A3(2).
J Bacteriol. 1999 Sep;181(17):5419-25. doi: 10.1128/JB.181.17.5419-5425.1999.
5
Initiation of aerial mycelium formation in Streptomyces.
Curr Opin Microbiol. 1998 Dec;1(6):656-62. doi: 10.1016/s1369-5274(98)80111-2.
6
Extracellular complementation and the identification of additional genes involved in aerial mycelium formation in Streptomyces coelicolor.
Genetics. 1999 Feb;151(2):569-84. doi: 10.1093/genetics/151.2.569.
7
A bacterial two-hybrid system based on a reconstituted signal transduction pathway.
Proc Natl Acad Sci U S A. 1998 May 12;95(10):5752-6. doi: 10.1073/pnas.95.10.5752.
8
The bldB gene encodes a small protein required for morphogenesis, antibiotic production, and catabolite control in Streptomyces coelicolor.
J Bacteriol. 1998 Mar;180(6):1556-62. doi: 10.1128/JB.180.6.1556-1562.1998.
9
Purification of an extracellular signaling molecule involved in production of aerial mycelium by Streptomyces coelicolor.
J Bacteriol. 1998 Mar;180(5):1334-7. doi: 10.1128/JB.180.5.1334-1337.1998.
10
An oligopeptide permease responsible for the import of an extracellular signal governing aerial mycelium formation in Streptomyces coelicolor.
Mol Microbiol. 1996 Dec;22(5):881-93. doi: 10.1046/j.1365-2958.1996.01540.x.
Zotero 插件