Rossmann Michael G, He Yongning, Kuhn Richard J
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907-1392, USA.
Trends Microbiol. 2002 Jul;10(7):324-31. doi: 10.1016/s0966-842x(02)02383-1.
Many picornaviruses use cell-surface molecules belonging to the immunoglobulin superfamily (IgSF) as their cellular receptors. These molecules usually consist of tandem repeats of between two and five Ig-like domains whose amino-terminal domains (D1) interact with invading viruses, with their carboxy-terminal sections comprising a transmembrane and a short cytoplasmic region. Most rhino- and enteroviruses, belonging to the Picornavirus family, use a canyon-like feature on their surface to attach to cellular receptors. Binding into the canyon destabilizes the virus and thus initiates the uncoating process. By contrast, non-IgSF molecules, when used by picornaviruses as receptors, bind outside the canyon and do not cause viral instability.
许多小核糖核酸病毒利用属于免疫球蛋白超家族（IgSF）的细胞表面分子作为其细胞受体。这些分子通常由两到五个免疫球蛋白样结构域的串联重复序列组成，其氨基末端结构域（D1）与入侵病毒相互作用，其羧基末端部分包括一个跨膜区和一个短的细胞质区域。属于小核糖核酸病毒科的大多数鼻病毒和肠道病毒利用其表面的峡谷样特征附着于细胞受体。结合到峡谷中会使病毒不稳定，从而启动脱壳过程。相比之下，当小核糖核酸病毒将非IgSF分子用作受体时，它们在峡谷外部结合，不会导致病毒不稳定。
