乌司他丁治疗胰腺癌的疗效。
Efficacy of ukrain in the treatment of pancreatic cancer.
作者信息
Zemskov Volodimir, Prokopchuk Olga, Susak Yaroslav, Zemskov Sergiy, Tkachenko Olexander, Hodysh Yuriy, Nowicky Wassil
机构信息
Department of General Surgery, National Medical University, prosp. Holosiivsky, 59B, 03039 Kyiv, Ukraine.
出版信息
Langenbecks Arch Surg. 2002 Jun;387(2):84-9. doi: 10.1007/s00423-002-0293-y. Epub 2002 Jun 19.
BACKGROUND
This monocentric study evaluated the effect of ukrain in the treatment of pancreatic cancer.
MATERIAL AND METHODS
Between January 1996 and December 1999 we treated 21 patients with 10 mg ukrain every second day x10. The control group received supportive treatment only.
RESULTS
Ukrain treatment was well tolerated. Mean values on pain measure and Karnofsky index were significantly better in the ukrain group than in controls ( P<0.05). One-year survival was 76% in the ukrain group, compared to 9.5% in the control group. Median survival after treatment with ukrain was 574 days, compared to 197 days in the control group.
CONCLUSIONS
Our data demonstrate that ukrain improves quality of life in patients suffering from advanced pancreatic cancer and significantly prolongs survival time in these patients.
背景
本单中心研究评估了乌头碱治疗胰腺癌的效果。
材料与方法
1996年1月至1999年12月期间，我们对21例患者每隔一天给予10毫克乌头碱，共10次。对照组仅接受支持治疗。
结果
乌头碱治疗耐受性良好。乌头碱组的疼痛测量平均值和卡诺夫斯基指数显著优于对照组（P<0.05）。乌头碱组的一年生存率为76%，而对照组为9.5%。乌头碱治疗后的中位生存期为574天，而对照组为197天。
结论
我们的数据表明，乌头碱可改善晚期胰腺癌患者的生活质量，并显著延长这些患者的生存时间。
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