儿童颅咽管瘤相关囊肿内液体分析：蛋白质、乳酸和pH值

Analysis of fluid in craniopharyngioma-related cysts in children: proteins, lactate and pH.

作者信息

Arefyeva I A, Semenova J B, Zubairaev M S, Kondrasheva E A, Moshkin A V

机构信息

Department Clinical Biochemistry, N.N. Burdenko Neurosurgical Institute, Moscow, Russia.

出版信息

Acta Neurochir (Wien). 2002 Jun;144(6):551-4; discussion 554. doi: 10.1007/s007010200077.

DOI:10.1007/s007010200077

PMID:12111487

Abstract

The purpose of this study was to evaluate the possible role of blood-brain barrier disruption in cyst formation in craniopharyngioma. Fifteen samples of cyst fluid and 14 samples of blood serum were collected from 14 patients with cystic forms of craniopharyngiomas and studied biochemically regarding total protein, albumin, immunoglobulins G and M contents, lactate and pH. Analysis of the data obtained for cyst fluids according to Felgenhauer and comparing them to those obtained for the corresponding blood sera led us to prove the hypothesis of blood-brain barrier impairment in patients with cyst formations in craniopharyngioma. We have also revealed an elevated lactate content and decreased pH in cyst fluids compared with blood sera. Thus the pathogenesis of craniopharyngiomal cyst appears to be much more akin to those described for cysts accompanying other brain tumours than it was believed earlier.

摘要

本研究的目的是评估血脑屏障破坏在颅咽管瘤囊肿形成中可能发挥的作用。从14例囊性颅咽管瘤患者中收集了15份囊液样本和14份血清样本，并对其总蛋白、白蛋白、免疫球蛋白G和M含量、乳酸和pH值进行了生化研究。根据费尔根豪尔对囊液数据的分析，并将其与相应血清的数据进行比较，我们证实了颅咽管瘤囊肿形成患者血脑屏障受损的假设。我们还发现，与血清相比，囊液中的乳酸含量升高，pH值降低。因此，颅咽管瘤囊肿的发病机制似乎比之前认为的更类似于其他脑肿瘤伴发囊肿的发病机制。