健康老年人脑白质高信号与内隐学习的关系。
The relation of White Matter Hyperintensities to implicit learning in healthy older adults.
作者信息
Aizenstein H J, Nebes R D, Meltzer C C, Fukui M B, Williams R L, Saxton J, Houck P R, Carter C S, Reynolds C F, DeKosky S T
机构信息
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
出版信息
Int J Geriatr Psychiatry. 2002 Jul;17(7):664-9. doi: 10.1002/gps.685.
OBJECTIVE
This study examined whether MRI evidence of cerebrovascular disease in the form of white matter hyperintensities (WMH) was associated with decreased implicit sequence learning performance in a high-functioning group of normal elderly volunteers.
METHOD
One hundred and eight community-dwelling elderly individuals received an MRI and performed an implicit sequence learning task, the serial reaction time (SRT) task.
RESULTS
Hyperintensities present in the white matter were associated with a decreased learning effect. This association was found with both deep white matter and periventricular changes. Other factors affecting SRT performance (i.e., baseline reaction time and switch-cost) were not significantly related to the presence of WMH.
CONCLUSIONS
The results indicate that in addition to previously identified generalized cognitive deficits, WMH are also associated with a specific decrease in the implicit learning of sequences.
目的
本研究探讨在一组功能正常的高龄志愿者中，以白质高信号（WMH）形式存在的脑血管疾病的MRI证据是否与内隐序列学习表现下降有关。
方法
108名居住在社区的老年人接受了MRI检查，并完成了一项内隐序列学习任务，即序列反应时（SRT）任务。
结果
白质中的高信号与学习效果下降有关。在深部白质和脑室周围变化中均发现了这种关联。影响SRT表现的其他因素（即基线反应时间和转换成本）与WMH的存在没有显著相关性。
结论
结果表明，除了先前确定的一般性认知缺陷外，WMH还与序列内隐学习的特定下降有关。
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